BIOSC 1540 - Project

Created: Nov. 15, 2024, 9:23 p.m. at 21:23

Models Name Description GMQE QSQE Seq Id Coverage Range Method Resolution Oligo-state Ligands Found by Seq Similarity
✓
 6pr6.1.A
Dihydrofolate reductase
S. aureus dihydrofolate reductase co-crystallized with para-tolyl-dihydropthalazine inhibitor and NADP(H)
 0.99 0.00 100.00 1.00 1-159 X-ray 2.01 monomer 1 x NAP, 1 x OWS HHblits 0.62
✓
 2w9g.1.A
DIHYDROFOLATE REDUCTASE
Wild-type Staphylococcus aureus DHFR in complex with NADPH and trimethoprim
 0.98 0.00 100.00 1.00 1-159 X-ray 1.95 monomer 1 x TOP, 1 x NDP HHblits 0.62
✓
 2w9h.1.A
DIHYDROFOLATE REDUCTASE
Wild-type Staphylococcus aureus DHFR in complex with trimethoprim
 0.97 0.00 100.00 1.00 1-159 X-ray 1.48 monomer 1 x TOP HHblits 0.62
✓
 3sqy.1.A
Dihydrofolate reductase
S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines
 0.98 0.00 100.00 1.00 1-159 X-ray 1.50 monomer 1 x NAP, 1 x Q11 HHblits 0.62
✓
 6e4e.1.A
Dihydrofolate reductase
Crystal structure of dihydrofolate reductase from Staphylococcus aureus MW2 bound to NADP and p218
 0.99 0.00 100.00 1.00 1-159 X-ray 1.90 monomer 1 x NAP, 1 x MMV HHblits 0.62
✓
 3sr5.1.A
Dihydrofolate reductase
S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines
 0.98 0.00 100.00 0.99 2-159 X-ray 1.68 monomer 1 x NAP, 1 x Q12 HHblits 0.62
✓
 6pr8.1.A
Dihydrofolate reductase
S. aureus dihydrofoate reductase co-crystallized with 3,5-dimethylphenyl-dihydropthalazine inhibitor and NADP(H)
 0.98 0.00 100.00 0.99 2-159 X-ray 2.01 monomer 1 x OWJ, 1 x NAP HHblits 0.62
✓
 3fyw.1.A
Dihydrofolate reductase
Staph. aureus DHFR complexed with NADPH and AR-101
 0.98 0.00 100.00 0.99 2-159 X-ray 2.10 monomer 1 x NDP, 1 x XCF HHblits 0.62
Q6G9D5.1.A
Dihydrofolate reductase
AlphaFold DB model of DYR_STAAS (gene: folA, organism: Staphylococcus aureus (strain MSSA476))
 0.98 98.74 1.00 1-159 AlphaFold v2 -1.00 monomer AFDB search 0.61
4q67.1.A
Dihydrofolate reductase
Staphylococcus aureus F98Y mutant dihydrofolate reductase complexed with NADPH
 0.98 99.37 0.99 1-158 X-ray 2.04 monomer 1 x NAP HHblits 0.62
3fy9.1.A
Dihydrofolate reductase
Staph. aureus DHFR F98Y complexed with AR-102
 0.97 99.37 0.99 2-159 X-ray 2.25 monomer 1 x NAP, 1 x XCF HHblits 0.62
4q6a.1.A
Dihydrofolate reductase
Staphylococcus aureus V31L, F98Y Mutant Dihydrofolate Reductase Complexed with NADPH
 0.98 98.73 0.99 1-158 X-ray 2.10 monomer 1 x NAP HHblits 0.62
3lg4.1.A
Dihydrofolate reductase
Staphylococcus aureus V31Y, F92I mutant dihydrofolate reductase complexed with NADPH and 5-[(3S)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
 0.95 98.73 0.99 1-158 X-ray 3.15 monomer 1 x NDP, 1 x 52V HHblits 0.61
3m08.1.A
Dihydrofolate reductase
Wild Type Dihydrofolate Reductase from Staphylococcus aureus with inhibitor RAB1
 0.98 100.00 0.99 2-158 X-ray 2.01 monomer 1 x RAR, 1 x NAP HHblits 0.62
4tu5.1.A
Dihydrofolate reductase
Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1062)
 0.97 100.00 0.99 2-158 X-ray 2.16 monomer 1 x NDP, 1 x 06W HHblits 0.62
4xe6.1.A
Dihydrofolate reductase
Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1061)
 0.97 100.00 0.99 1-157 X-ray 2.69 monomer 1 x 06U, 1 x NDP HHblits 0.62
5hf0.1.A
Dihydrofolate reductase
Staphylococcus aureus Dihydrofolate Reductase complexed with beta-NADPH, cyclic alpha-NADPH anomer and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (UCP1106)
 0.98 100.00 0.99 2-158 X-ray 2.25 monomer 1 x U06, 1 x XNP, 1 x NAP HHblits 0.62
3sgy.1.A
Dihydrofolate reductase
Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006)
 0.97 100.00 0.99 2-158 X-ray 2.60 monomer 1 x NDP, 1 x 06W HHblits 0.62
3f0u.1.A
Trimethoprim-sensitive dihydrofolate reductase
Staphylococcus aureus F98Y mutant dihydrofolate reductase complexed with NADPH and 2,4-Diamino-5-[3-(3-methoxy-5-phenylphenyl)but-1-ynyl]-6-methylpyrimidine
 0.98 99.36 0.99 2-158 X-ray 1.60 monomer 1 x NDP, 1 x 53R HHblits 0.62
5isp.1.A
Dihydrofolate reductase
Staphylococcus aureus F98Y Dihydrofolate Reductase mutant complexed with beta-NADPH and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (UCP1106)
 0.98 99.36 0.99 2-158 X-ray 1.84 monomer 1 x NAP, 1 x U06 HHblits 0.62
3m09.1.A
Dihydrofolate reductase
F98Y TMP-resistant Dihydrofolate Reductase from Staphylococcus aureus with inhibitor RAB1
 0.98 99.36 0.99 2-158 X-ray 2.01 monomer 1 x RAR, 1 x NAP HHblits 0.62
5ist.1.A
Dihydrofolate reductase
Staphylococcus aureus Dihydrofolate Reductase complexed with beta-NADPH, cyclic alpha-NADPH anomer and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (UCP1106)
 0.98 99.36 0.99 2-158 X-ray 1.72 monomer 1 x U06, 1 x XNP, 1 x NAP HHblits 0.62
3i8a.1.A
Dihydrofolate reductase
Staphylococcus aureus H30N, F98Y Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)
 0.97 98.73 0.99 2-158 X-ray 2.41 monomer 1 x N22, 1 x NDP HHblits 0.62
5isq.1.A
Dihydrofolate reductase
Staphylococcus aureus H30N, F98Y Dihydrofolate Reductase mutant complexed with beta-NADPH and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (UCP1106)
 0.98 98.73 0.99 2-158 X-ray 1.90 monomer 1 x NAP, 1 x U06 HHblits 0.62
2w9s.1.A
DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003
Staphylococcus aureus S1:DHFR in complex with trimethoprim
 0.94 0.00 81.13 1.00 1-159 X-ray 1.80 monomer 1 x NDP, 1 x TOP BLAST 0.56
2w9t.1.A
DIHYDROFOLATE REDUCTASE TYPE 1
Staphylococcus aureus S1:DHFR
 0.89 0.00 81.13 1.00 1-159 X-ray 2.35 monomer BLAST 0.56
2w9s.1.A
DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003
Staphylococcus aureus S1:DHFR in complex with trimethoprim
 0.94 0.00 81.01 0.99 1-158 X-ray 1.80 monomer 1 x NDP, 1 x TOP HHblits 0.56
2w9t.1.A
DIHYDROFOLATE REDUCTASE TYPE 1
Staphylococcus aureus S1:DHFR
 0.89 0.00 81.01 0.99 1-158 X-ray 2.35 monomer HHblits 0.56
1zdr.1.A
dihydrofolate reductase
DHFR from Bacillus Stearothermophilus
 0.81 50.00 0.99 2-159 X-ray 2.00 monomer HHblits 0.44
1zdr.2.A
dihydrofolate reductase
DHFR from Bacillus Stearothermophilus
 0.81 50.00 0.99 2-159 X-ray 2.00 monomer HHblits 0.44
1zdr.1.A
dihydrofolate reductase
DHFR from Bacillus Stearothermophilus
 0.81 50.32 0.99 3-159 X-ray 2.00 monomer BLAST 0.44
1zdr.2.A
dihydrofolate reductase
DHFR from Bacillus Stearothermophilus
 0.80 50.32 0.99 3-159 X-ray 2.00 monomer BLAST 0.44
3jw5.1.A
Dihydrofolate reductase
Crystal structure of Bacillus anthracis (Y102F) dihydrofolate reductase complexed with NADPH and Trimethoprim
 0.74 45.86 0.99 1-159 X-ray 2.89 monomer 1 x NDP, 1 x TOP BLAST 0.44
2qk8.1.A
Dihydrofolate reductase
Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductase
 0.72 45.22 0.99 1-159 X-ray 2.40 monomer 1 x MTX BLAST 0.44
3dat.1.A
Dihydrofolate reductase
Crystal structure of the ternary MTX NADPH complex of Bacillus anthracis dihydrofolate reductase
 0.73 45.22 0.99 1-159 X-ray 2.30 monomer 1 x MTX, 1 x NDP BLAST 0.44
8ssx.1.A
Dihydrofolate reductase
Crystal structure of Bacillus anthracis dihydrofolate reductase at 1.65-A resolution
 0.66 45.22 0.99 1-159 X-ray 1.65 monomer BLAST 0.44
3fl8.5.A
Dihydrofolate reductase
Crystal structure of B. anthracis dihydrofolate reductase (DHFR) with RAB1, a TMP-dihydrophthalazine derivative
 0.74 45.22 0.99 1-159 X-ray 2.29 monomer 1 x CA, 1 x RAR BLAST 0.44
3fl9.2.A
dihydrofolate reductase (DHFR)
Crystal structure of B. anthracis dihydrofolate reductase (DHFR) with trimethoprim
 0.72 45.22 0.99 1-159 X-ray 2.40 monomer 1 x CA, 1 x TOP BLAST 0.44
3jvx.1.A
Dihydrofolate reductase
Crystal structure of Bacillus anthracis dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-(3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120A)
 0.75 45.22 0.99 1-159 X-ray 2.25 homo-dimer 2 x NDP, 2 x EKB BLAST 0.44
2kgk.1.A
Dihydrofolate reductase
Solution structure of Bacillus anthracis dihydrofolate reductase
 0.59 45.22 0.99 1-159 NMR 0.00 monomer 1 x NAP, 1 x N22 BLAST 0.44
3sai.2.A
Dihydrofolate reductase
Bacuills anthracis Dihydrofolate Reductase bound to propargyl-linked TMP analog, UCP1015
 0.75 45.22 0.99 1-159 X-ray 2.25 monomer 1 x NAP, 1 x 9DR BLAST 0.44
3e0b.1.A
Dihydrofolate reductase
Bacillus anthracis Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)
 0.75 45.22 0.99 1-159 X-ray 2.25 monomer 1 x NDP, 1 x N22 BLAST 0.44
3jw5.1.A
Dihydrofolate reductase
Crystal structure of Bacillus anthracis (Y102F) dihydrofolate reductase complexed with NADPH and Trimethoprim
 0.82 43.40 1.00 1-159 X-ray 2.89 monomer 1 x NDP, 1 x TOP HHblits 0.43
3jw3.1.A
Dihydrofolate reductase
Crystal structure of Bacillus anthracis (F96I) dihydrofolate reductase complexed with NADPH and Trimethoprim
 0.74 44.59 0.99 1-159 X-ray 2.57 monomer 1 x NDP, 1 x TOP BLAST 0.44
2qk8.1.A
Dihydrofolate reductase
Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductase
 0.79 42.77 1.00 1-159 X-ray 2.40 monomer 1 x MTX HHblits 0.43
3dat.1.A
Dihydrofolate reductase
Crystal structure of the ternary MTX NADPH complex of Bacillus anthracis dihydrofolate reductase
 0.80 42.77 1.00 1-159 X-ray 2.30 monomer 1 x MTX, 1 x NDP HHblits 0.43
8ssx.1.A
Dihydrofolate reductase
Crystal structure of Bacillus anthracis dihydrofolate reductase at 1.65-A resolution
 0.74 42.77 1.00 1-159 X-ray 1.65 monomer HHblits 0.43
3jvx.1.A
Dihydrofolate reductase
Crystal structure of Bacillus anthracis dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-(3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120A)
 0.82 42.77 1.00 1-159 X-ray 2.25 homo-dimer 2 x NDP, 2 x EKB HHblits 0.43
3e0b.1.A
Dihydrofolate reductase
Bacillus anthracis Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)
 0.82 42.77 1.00 1-159 X-ray 2.25 monomer 1 x NDP, 1 x N22 HHblits 0.43
3tq8.1.A
Dihydrofolate reductase
Structure of the dihydrofolate reductase (folA) from Coxiella burnetii in complex with trimethoprim
 0.81 43.04 0.99 1-158 X-ray 1.90 monomer 1 x NDP, 1 x TOP HHblits 0.43
3tq8.1.A
Dihydrofolate reductase
Structure of the dihydrofolate reductase (folA) from Coxiella burnetii in complex with trimethoprim
 0.81 43.31 0.99 1-157 X-ray 1.90 monomer 1 x NDP, 1 x TOP BLAST 0.43
3fl8.5.A
Dihydrofolate reductase
Crystal structure of B. anthracis dihydrofolate reductase (DHFR) with RAB1, a TMP-dihydrophthalazine derivative
 0.81 43.04 0.99 1-158 X-ray 2.29 monomer 1 x CA, 1 x RAR HHblits 0.43
3fl9.2.A
dihydrofolate reductase (DHFR)
Crystal structure of B. anthracis dihydrofolate reductase (DHFR) with trimethoprim
 0.79 43.04 0.99 1-158 X-ray 2.40 monomer 1 x CA, 1 x TOP HHblits 0.43
2kgk.1.A
Dihydrofolate reductase
Solution structure of Bacillus anthracis dihydrofolate reductase
 0.64 43.04 0.99 1-158 NMR 0.00 monomer 1 x NAP, 1 x N22 HHblits 0.43
3sai.2.A
Dihydrofolate reductase
Bacuills anthracis Dihydrofolate Reductase bound to propargyl-linked TMP analog, UCP1015
 0.82 43.04 0.99 1-158 X-ray 2.25 monomer 1 x NAP, 1 x 9DR HHblits 0.43
8uvz.1.A
Dihydrofolate reductase
Bacillus subtilis DHFR bound to NADP+ and folate
 0.82 43.31 0.99 2-158 X-ray 0.93 monomer 1 x FOL, 1 x NAP HHblits 0.43
3jw3.1.A
Dihydrofolate reductase
Crystal structure of Bacillus anthracis (F96I) dihydrofolate reductase complexed with NADPH and Trimethoprim
 0.81 42.41 0.99 1-158 X-ray 2.57 monomer 1 x NDP, 1 x TOP HHblits 0.42
8uvz.1.A
Dihydrofolate reductase
Bacillus subtilis DHFR bound to NADP+ and folate
 0.82 43.59 0.98 3-158 X-ray 0.93 monomer 1 x FOL, 1 x NAP BLAST 0.43
4m7v.1.A
Dihydrofolate reductase
Dihydrofolate reductase from Enterococcus faecalis complexed with NADP(H)and RAB-propyl
 0.77 45.57 0.99 2-159 X-ray 2.30 monomer 1 x RAR, 1 x NAP HHblits 0.42
4m7u.1.A
Dihydrofolate reductase
Dihydrofolate reductase from Enterococcus faecalis complexed with NADP(H)
 0.77 45.57 0.99 2-159 X-ray 2.10 monomer 1 x NAP HHblits 0.42
7tj3.1.A
Dihydrofolate reductase
Crystal structure of a dihydrofolate reductase folA from Stenotrophomonas maltophilia bound to NADP and p218
 0.80 38.61 0.99 1-158 X-ray 1.55 monomer 1 x NAP, 1 x MMV HHblits 0.40
3ia4.1.A
Dihydrofolate reductase
Moritella profunda dihydrofolate reductase (DHFR) in complex with NADPH and methotrexate (MTX)
 0.81 39.62 1.00 1-159 X-ray 1.70 monomer 1 x NDP, 1 x MTX HHblits 0.40
3ia5.1.A
Dihydrofolate reductase
Moritella profunda dihydrofolate reductase (DHFR)
 0.78 39.62 1.00 1-159 X-ray 2.10 monomer HHblits 0.40
2zza.1.A
Dihydrofolate reductase
Moritella profunda Dihydrofolate reductase complex with NADP+ and Folate
 0.81 38.99 1.00 1-159 X-ray 2.00 monomer 1 x NAP, 1 x FOL HHblits 0.40
3q1h.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate Reductase from Yersinia pestis
 0.68 40.13 0.99 1-158 X-ray 1.80 monomer BLAST 0.40
5hi6.1.A
Dihydrofolate reductase
The high resolution structure of dihydrofolate reductase from Yersinia pestis complex with methotrexate as closed form
 0.76 40.13 0.99 1-158 X-ray 2.05 monomer 1 x MTX, 1 x CA, 1 x K BLAST 0.40
5hi6.2.A
Dihydrofolate reductase
The high resolution structure of dihydrofolate reductase from Yersinia pestis complex with methotrexate as closed form
 0.76 40.13 0.99 1-158 X-ray 2.05 monomer 1 x MTX, 1 x K BLAST 0.40
8sze.1.A
Dihydrofolate reductase
Crystal structure of Yersinia pestis dihydrofolate reductase in complex with Trimethoprim
 0.74 40.13 0.99 1-158 X-ray 2.50 monomer 1 x TOP BLAST 0.40
8szd.1.A
Dihydrofolate reductase
Crystal structure of Yersinia pestis dihydrofolate reductase at 1.25-A resolution
 0.67 40.13 0.99 1-158 X-ray 1.25 monomer 1 x MG BLAST 0.40
4qi9.2.A
Dihydrofolate reductase
Crystal structure of dihydrofolate reductase from Yersinia pestis complexed with methotrexate
 0.76 40.13 0.99 1-158 X-ray 2.30 monomer 1 x MTX BLAST 0.40
4qi9.1.A
Dihydrofolate reductase
Crystal structure of dihydrofolate reductase from Yersinia pestis complexed with methotrexate
 0.76 40.13 0.99 1-158 X-ray 2.30 monomer 1 x MTX BLAST 0.40
4qi9.2.A
Dihydrofolate reductase
Crystal structure of dihydrofolate reductase from Yersinia pestis complexed with methotrexate
 0.77 39.49 0.99 1-158 X-ray 2.30 monomer 1 x MTX HHblits 0.40
4qi9.1.A
Dihydrofolate reductase
Crystal structure of dihydrofolate reductase from Yersinia pestis complexed with methotrexate
 0.76 39.49 0.99 1-158 X-ray 2.30 monomer 1 x MTX HHblits 0.40
8sze.1.A
Dihydrofolate reductase
Crystal structure of Yersinia pestis dihydrofolate reductase in complex with Trimethoprim
 0.74 39.49 0.99 1-158 X-ray 2.50 monomer 1 x TOP HHblits 0.40
8szd.1.A
Dihydrofolate reductase
Crystal structure of Yersinia pestis dihydrofolate reductase at 1.25-A resolution
 0.68 39.49 0.99 1-158 X-ray 1.25 monomer 1 x MG HHblits 0.40
3q1h.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate Reductase from Yersinia pestis
 0.68 39.49 0.99 1-158 X-ray 1.80 monomer HHblits 0.40
5hi6.1.A
Dihydrofolate reductase
The high resolution structure of dihydrofolate reductase from Yersinia pestis complex with methotrexate as closed form
 0.76 39.49 0.99 1-158 X-ray 2.05 monomer 1 x MTX, 1 x CA, 1 x K HHblits 0.40
5hi6.2.A
Dihydrofolate reductase
The high resolution structure of dihydrofolate reductase from Yersinia pestis complex with methotrexate as closed form
 0.77 39.49 0.99 1-158 X-ray 2.05 monomer 1 x MTX, 1 x K HHblits 0.40
8f09.1.A
Dihydrofolate reductase
Crystal structure of a trimethoprim-resistant dihydrofolate reductase (DHFR) enzyme from an uncultured soil bacterium
 0.76 36.08 0.99 1-158 X-ray 2.45 monomer HHblits 0.39
8f09.2.A
Dihydrofolate reductase
Crystal structure of a trimethoprim-resistant dihydrofolate reductase (DHFR) enzyme from an uncultured soil bacterium
 0.75 36.08 0.99 1-158 X-ray 2.45 monomer HHblits 0.39
4m7u.1.A
Dihydrofolate reductase
Dihydrofolate reductase from Enterococcus faecalis complexed with NADP(H)
 0.76 48.00 0.94 3-152 X-ray 2.10 monomer 1 x NAP BLAST 0.43
4m7v.1.A
Dihydrofolate reductase
Dihydrofolate reductase from Enterococcus faecalis complexed with NADP(H)and RAB-propyl
 0.76 48.00 0.94 3-152 X-ray 2.30 monomer 1 x RAR, 1 x NAP BLAST 0.43
3ix9.1.A
Dihydrofolate reductase
Crystal structure of Streptococcus pneumoniae dihydrofolate reductase - Sp9 mutant
 0.68 35.03 0.99 1-159 X-ray 1.95 homo-dimer 2 x NDP, 2 x MTX BLAST 0.39
3ix9.1.B
Dihydrofolate reductase
Crystal structure of Streptococcus pneumoniae dihydrofolate reductase - Sp9 mutant
 0.69 35.03 0.99 1-159 X-ray 1.95 homo-dimer 2 x NDP, 2 x MTX BLAST 0.39
5uio.1.A
Dihydrofolate reductase
structure of DHFR with bound DAP, p-ABG and NADP
 0.76 0.00 36.31 0.99 1-158 X-ray 1.93 monomer 1 x LG3, 1 x 8DM, 1 x NAP BLAST 0.39
5uio.4.A
Dihydrofolate reductase
structure of DHFR with bound DAP, p-ABG and NADP
 0.79 0.00 36.31 0.99 1-158 X-ray 1.93 monomer 1 x LG3, 1 x 8DM, 1 x NAP BLAST 0.39
3ix9.1.A
Dihydrofolate reductase
Crystal structure of Streptococcus pneumoniae dihydrofolate reductase - Sp9 mutant
 0.78 32.08 1.00 1-159 X-ray 1.95 homo-dimer 2 x NDP, 2 x MTX HHblits 0.38
3ix9.1.B
Dihydrofolate reductase
Crystal structure of Streptococcus pneumoniae dihydrofolate reductase - Sp9 mutant
 0.79 32.08 1.00 1-159 X-ray 1.95 homo-dimer 2 x NDP, 2 x MTX HHblits 0.38
5uio.1.A
Dihydrofolate reductase
structure of DHFR with bound DAP, p-ABG and NADP
 0.77 0.00 35.03 0.99 1-158 X-ray 1.93 monomer 1 x LG3, 1 x 8DM, 1 x NAP HHblits 0.39
5uio.4.A
Dihydrofolate reductase
structure of DHFR with bound DAP, p-ABG and NADP
 0.80 0.00 35.03 0.99 1-158 X-ray 1.93 monomer 1 x LG3, 1 x 8DM, 1 x NAP HHblits 0.39
2d0k.1.A
Dihydrofolate reductase
Methionine-free mutant of Escherichia coli dihydrofolate reductase
 0.75 0.00 36.54 0.98 2-158 X-ray 1.90 monomer 1 x FOL BLAST 0.39
2d0k.2.A
Dihydrofolate reductase
Methionine-free mutant of Escherichia coli dihydrofolate reductase
 0.75 0.00 36.54 0.98 2-158 X-ray 1.90 monomer 1 x FOL BLAST 0.39
2d0k.1.A
Dihydrofolate reductase
Methionine-free mutant of Escherichia coli dihydrofolate reductase
 0.75 35.26 0.98 2-158 X-ray 1.90 monomer 1 x FOL HHblits 0.39
2d0k.2.A
Dihydrofolate reductase
Methionine-free mutant of Escherichia coli dihydrofolate reductase
 0.76 35.26 0.98 2-158 X-ray 1.90 monomer 1 x FOL HHblits 0.39
5uii.1.A
Dihydrofolate reductase
structure of DHFR with bound buformin and NADP
 0.75 0.00 36.13 0.97 3-158 X-ray 1.35 monomer 1 x NAP, 1 x CA, 1 x BFR BLAST 0.39
5uih.1.A
Dihydrofolate reductase
structure of DHFR with bound phenformin and NADP
 0.75 0.00 34.62 0.98 2-158 X-ray 1.65 monomer 1 x 8CV, 1 x NAP HHblits 0.39
6cxk.1.A
Dihydrofolate reductase
E. coli DHFR substrate complex with Dihydrofolate
 0.75 34.62 0.98 2-158 X-ray 1.11 monomer 7 x MG, 1 x DHF HHblits 0.39
6cqa.1.A
Dihydrofolate reductase
E. coli DHFR complex with inhibitor AMPQD
 0.74 34.62 0.98 2-158 X-ray 2.20 monomer 1 x PQD HHblits 0.39
6cyv.1.A
Dihydrofolate reductase
E. coli DHFR ternary complex with NADP and dihydrofolate
 0.76 34.62 0.98 2-158 X-ray 1.30 monomer 1 x NAP, 1 x DHF HHblits 0.39
6xg5.1.A
Dihydrofolate reductase
X-ray structure of Escherichia coli dihydrofolate reductase in complex with trimethoprim
 0.79 34.62 0.98 2-158 X-ray 1.90 monomer 1 x NDP, 1 x TOP HHblits 0.39
7f3b.1.A
Dihydrofolate reductase
cocrystallization of Escherichia coli dihydrofolate reductase (DHFR) and its pyrrolo[3,2-f]quinazoline inhibitor.
 0.73 34.62 0.98 2-158 X-ray 2.81 monomer 1 x D4C HHblits 0.39
7mym.3.A
Dihydrofolate reductase
Crystal structure of Escherichia coli dihydrofolate reductase in complex with TRIMETHOPRIM and NADPH
 0.79 34.62 0.98 2-158 X-ray 3.04 monomer 1 x NAP, 1 x TOP HHblits 0.39
1dds.1.B
DIHYDROFOLATE REDUCTASE
MOLECULE: DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE
 0.76 34.62 0.98 2-158 X-ray 2.20 homo-dimer 2 x MTX, 1 x CA HHblits 0.39
4eiz.1.A
Dihydrofolate reductase
Structure of Nb113 bound to apoDHFR
 0.75 34.62 0.98 2-158 X-ray 2.20 hetero-oligomer HHblits 0.39
3dau.1.A
Dihydrofolate reductase
Crystal structure of the ternary MTX NADPH complex of Escherichia coli dihydrofolate reductase
 0.78 34.62 0.98 2-158 X-ray 1.50 monomer 1 x MTX, 1 x NDP HHblits 0.39
4pth.1.A
Dihydrofolate reductase
Ensemble model for Escherichia coli dihydrofolate reductase at 100K
 0.78 34.62 0.98 2-158 X-ray 0.85 monomer 1 x FOL, 1 x NAP, 2 x MN HHblits 0.39
5ccc.1.A
Dihydrofolate reductase
wild-type E.coli dihydrofolate reductase complexed with 5,10-dideazatetrahydrofolate and oxidized nicotinamide adenine dinucleotide phosphate
 0.75 34.62 0.98 2-158 X-ray 1.50 monomer 1 x DDF, 1 x NAP HHblits 0.39
8ucx.1.A
Dihydrofolate reductase
Dihydrofolate Reductase Complexed with Folate
 0.75 34.62 0.98 2-158 X-ray 1.57 monomer 1 x FOL, 3 x MN HHblits 0.39
4p3q.1.A
Dihydrofolate reductase
Room-temperature WT DHFR, time-averaged ensemble
 0.79 34.62 0.98 2-158 X-ray 1.35 monomer 1 x FOL, 1 x CA, 1 x NAP HHblits 0.39
4p3r.1.A
Dihydrofolate reductase
Cryogenic WT DHFR, time-averaged ensemble
 0.79 34.62 0.98 2-158 X-ray 1.15 monomer 1 x FOL, 1 x NAP HHblits 0.39
1ddr.1.A
DIHYDROFOLATE REDUCTASE
MOLECULE: DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE AND UREA
 0.74 34.62 0.98 2-158 X-ray 2.45 homo-dimer 2 x MTX, 1 x CA HHblits 0.39
1ddr.1.B
DIHYDROFOLATE REDUCTASE
MOLECULE: DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE AND UREA
 0.75 34.62 0.98 2-158 X-ray 2.45 homo-dimer 2 x MTX, 1 x CA HHblits 0.39
4kjk.1.A
Dihydrofolate reductase
Room Temperature WT DHFR
 0.79 34.62 0.98 2-158 X-ray 1.35 monomer 1 x FOL, 1 x CA, 1 x NAP HHblits 0.39
4eig.1.A
Dihydrofolate reductase
CA1698 camel antibody fragment in complex with DHFR
 0.74 34.62 0.98 2-158 X-ray 2.50 hetero-1-1-mer HHblits 0.39
4ptj.1.A
Dihydrofolate reductase
Ensemble model for Escherichia coli dihydrofolate reductase at 277K
 0.78 34.62 0.98 2-158 X-ray 1.05 monomer 1 x FOL, 1 x NAP, 2 x MN HHblits 0.39
3k74.1.A
Dihydrofolate reductase
Disruption of protein dynamics by an allosteric effector antibody
 0.74 34.62 0.98 2-158 X-ray 1.95 hetero-1-1-mer HHblits 0.39
1tdr.1.B
TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE
EXPRESSION, CHARACTERIZATION, AND CRYSTALLOGRAPHIC ANALYSIS OF TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE
 0.76 34.62 0.98 2-158 X-ray 2.50 homo-dimer 2 x MTX, 4 x TE, 1 x CA HHblits 0.39
1tdr.1.A
TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE
EXPRESSION, CHARACTERIZATION, AND CRYSTALLOGRAPHIC ANALYSIS OF TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE
 0.75 34.62 0.98 2-158 X-ray 2.50 homo-dimer 2 x MTX, 4 x TE, 1 x CA HHblits 0.39
7nae.1.A
Dihydrofolate reductase
Crystal structure of Escherichia coli dihydrofolate reductase in complex with TRIMETHOPRIM
 0.74 34.62 0.98 2-158 X-ray 2.35 homo-dimer 2 x TOP HHblits 0.39
4x5i.1.A
Dihydrofolate reductase
ecDHFR complexed with folate and NADP+ at 660 MPa
 0.75 34.62 0.98 2-158 X-ray 1.80 monomer 1 x FOL, 1 x NAP HHblits 0.39
5z6k.1.A
Dihydrofolate reductase
High-pressure Crystal Structure Analysis of M20 loop closed DHFR at 400 MPa
 0.79 34.62 0.98 2-158 X-ray 1.80 monomer 1 x FOL, 1 x NAP HHblits 0.39
5z6l.1.A
Dihydrofolate reductase
High-pressure Crystal Structure Analysis of M20 loop closed DHFR at 650 MPa
 0.77 34.62 0.98 2-158 X-ray 1.90 monomer 1 x FOL, 1 x NAP HHblits 0.39
5z6m.1.A
Dihydrofolate reductase
High-pressure Crystal Structure Analysis of M20 loop closed DHFR at 800 MPa
 0.75 34.62 0.98 2-158 X-ray 2.20 monomer 1 x FOL, 1 x NAP HHblits 0.39
8v9r.1.G
Dihydrofolate reductase
Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Branched-Degron DHFR-ssrA Substrate Bound with MTX
 0.74 34.62 0.98 2-158 EM 0.00 hetero-6-1-14-mer 3 x ATP, 4 x MG, 3 x ADP, 1 x MTX HHblits 0.39
1rb2.1.A
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)
 0.76 34.62 0.98 2-158 X-ray 2.10 homo-dimer 2 x FOL, 2 x NAP HHblits 0.39
2inq.1.A
Dihydrofolate reductase
Neutron Crystal Structure of Escherichia coli Dihydrofolate Reductase Bound to the Anti-cancer drug, Methotrexate
 0.71 34.62 0.98 2-158 neutron diff. 2.20 monomer 1 x MT1 HHblits 0.39
1rh3.1.A
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM)
 0.78 34.62 0.98 2-158 X-ray 2.40 monomer 1 x MTX, 1 x NAP HHblits 0.39
3kfy.1.A
Dihydrofolate reductase
Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR
 0.78 34.62 0.98 2-158 X-ray 2.08 monomer 1 x NDP, 1 x JZM, 3 x CA HHblits 0.39
1rf7.1.A
DIHYDROFOLATE REDUCTASE
STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDROFOLATE
 0.76 34.62 0.98 2-158 X-ray 1.80 monomer 1 x MN, 2 x DHF HHblits 0.39
3r33.1.A
Dihydrofolate reductase
Evidence for dynamic motion in proteins as a mechanism for ligand dissociation
 0.79 34.62 0.98 2-158 X-ray 2.09 monomer 1 x 6ME, 1 x NDP, 16 x CA HHblits 0.39
1rg7.1.A
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE
 0.73 34.62 0.98 2-158 X-ray 2.00 monomer 1 x MTX HHblits 0.39
4qlg.1.A
Dihydrofolate reductase
Crystal structure of I14V DHFR mutant complexed with folate and NADP+
 0.76 33.97 0.98 2-158 X-ray 1.50 monomer 1 x FOL, 1 x NAP HHblits 0.39
7mqp.1.A
Dihydrofolate reductase
E. coli dihydrofolate reductase complexed with 4'-chloro-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-[1,1'-biphenyl]-4-carboxamide (UCP1228)
 0.74 34.62 0.98 2-158 X-ray 2.10 homo-dimer 2 x ZM4 HHblits 0.39
1dhj.1.A
DIHYDROFOLATE REDUCTASE
LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE
 0.75 34.62 0.98 2-158 X-ray 1.80 homo-dimer 2 x MTX, 1 x CA HHblits 0.39
1dhj.1.B
DIHYDROFOLATE REDUCTASE
LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE
 0.76 34.62 0.98 2-158 X-ray 1.80 homo-dimer 2 x MTX, 1 x CA HHblits 0.39
1tdr.1.B
TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE
EXPRESSION, CHARACTERIZATION, AND CRYSTALLOGRAPHIC ANALYSIS OF TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE
 0.74 36.13 0.97 3-158 X-ray 2.50 homo-dimer 2 x MTX, 4 x TE, 1 x CA BLAST 0.39
1tdr.1.A
TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE
EXPRESSION, CHARACTERIZATION, AND CRYSTALLOGRAPHIC ANALYSIS OF TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE
 0.73 36.13 0.97 3-158 X-ray 2.50 homo-dimer 2 x MTX, 4 x TE, 1 x CA BLAST 0.39
7mym.3.A
Dihydrofolate reductase
Crystal structure of Escherichia coli dihydrofolate reductase in complex with TRIMETHOPRIM and NADPH
 0.78 36.13 0.97 3-158 X-ray 3.04 monomer 1 x NAP, 1 x TOP BLAST 0.39
1dds.1.B
DIHYDROFOLATE REDUCTASE
MOLECULE: DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE
 0.75 36.13 0.97 3-158 X-ray 2.20 homo-dimer 2 x MTX, 1 x CA BLAST 0.39
4eiz.1.A
Dihydrofolate reductase
Structure of Nb113 bound to apoDHFR
 0.73 36.13 0.97 3-158 X-ray 2.20 hetero-oligomer BLAST 0.39
3dau.1.A
Dihydrofolate reductase
Crystal structure of the ternary MTX NADPH complex of Escherichia coli dihydrofolate reductase
 0.77 36.13 0.97 3-158 X-ray 1.50 monomer 1 x MTX, 1 x NDP BLAST 0.39
4pth.1.A
Dihydrofolate reductase
Ensemble model for Escherichia coli dihydrofolate reductase at 100K
 0.77 36.13 0.97 3-158 X-ray 0.85 monomer 1 x FOL, 1 x NAP, 2 x MN BLAST 0.39
5ccc.1.A
Dihydrofolate reductase
wild-type E.coli dihydrofolate reductase complexed with 5,10-dideazatetrahydrofolate and oxidized nicotinamide adenine dinucleotide phosphate
 0.74 36.13 0.97 3-158 X-ray 1.50 monomer 1 x DDF, 1 x NAP BLAST 0.39
8ucx.1.A
Dihydrofolate reductase
Dihydrofolate Reductase Complexed with Folate
 0.74 36.13 0.97 3-158 X-ray 1.57 monomer 1 x FOL, 3 x MN BLAST 0.39
4p3q.1.A
Dihydrofolate reductase
Room-temperature WT DHFR, time-averaged ensemble
 0.78 36.13 0.97 3-158 X-ray 1.35 monomer 1 x FOL, 1 x CA, 1 x NAP BLAST 0.39
4p3r.1.A
Dihydrofolate reductase
Cryogenic WT DHFR, time-averaged ensemble
 0.78 36.13 0.97 3-158 X-ray 1.15 monomer 1 x FOL, 1 x NAP BLAST 0.39
1ddr.1.A
DIHYDROFOLATE REDUCTASE
MOLECULE: DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE AND UREA
 0.73 36.13 0.97 3-158 X-ray 2.45 homo-dimer 2 x MTX, 1 x CA BLAST 0.39
1ddr.1.B
DIHYDROFOLATE REDUCTASE
MOLECULE: DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEXED WITH METHOTREXATE AND UREA
 0.74 36.13 0.97 3-158 X-ray 2.45 homo-dimer 2 x MTX, 1 x CA BLAST 0.39
4kjk.1.A
Dihydrofolate reductase
Room Temperature WT DHFR
 0.77 36.13 0.97 3-158 X-ray 1.35 monomer 1 x FOL, 1 x CA, 1 x NAP BLAST 0.39
4eig.1.A
Dihydrofolate reductase
CA1698 camel antibody fragment in complex with DHFR
 0.73 36.13 0.97 3-158 X-ray 2.50 hetero-1-1-mer BLAST 0.39
4ptj.1.A
Dihydrofolate reductase
Ensemble model for Escherichia coli dihydrofolate reductase at 277K
 0.77 36.13 0.97 3-158 X-ray 1.05 monomer 1 x FOL, 1 x NAP, 2 x MN BLAST 0.39
3k74.1.A
Dihydrofolate reductase
Disruption of protein dynamics by an allosteric effector antibody
 0.73 36.13 0.97 3-158 X-ray 1.95 hetero-1-1-mer BLAST 0.39
7nae.1.A
Dihydrofolate reductase
Crystal structure of Escherichia coli dihydrofolate reductase in complex with TRIMETHOPRIM
 0.72 36.13 0.97 3-158 X-ray 2.35 homo-dimer 2 x TOP BLAST 0.39
4x5i.1.A
Dihydrofolate reductase
ecDHFR complexed with folate and NADP+ at 660 MPa
 0.74 36.13 0.97 3-158 X-ray 1.80 monomer 1 x FOL, 1 x NAP BLAST 0.39
5z6k.1.A
Dihydrofolate reductase
High-pressure Crystal Structure Analysis of M20 loop closed DHFR at 400 MPa
 0.78 36.13 0.97 3-158 X-ray 1.80 monomer 1 x FOL, 1 x NAP BLAST 0.39
5z6l.1.A
Dihydrofolate reductase
High-pressure Crystal Structure Analysis of M20 loop closed DHFR at 650 MPa
 0.76 36.13 0.97 3-158 X-ray 1.90 monomer 1 x FOL, 1 x NAP BLAST 0.39
5z6m.1.A
Dihydrofolate reductase
High-pressure Crystal Structure Analysis of M20 loop closed DHFR at 800 MPa
 0.74 36.13 0.97 3-158 X-ray 2.20 monomer 1 x FOL, 1 x NAP BLAST 0.39
6cxk.1.A
Dihydrofolate reductase
E. coli DHFR substrate complex with Dihydrofolate
 0.74 36.13 0.97 3-158 X-ray 1.11 monomer 7 x MG, 1 x DHF BLAST 0.39
6cqa.1.A
Dihydrofolate reductase
E. coli DHFR complex with inhibitor AMPQD
 0.73 36.13 0.97 3-158 X-ray 2.20 monomer 1 x PQD BLAST 0.39
6cyv.1.A
Dihydrofolate reductase
E. coli DHFR ternary complex with NADP and dihydrofolate
 0.75 36.13 0.97 3-158 X-ray 1.30 monomer 1 x NAP, 1 x DHF BLAST 0.39
6xg5.1.A
Dihydrofolate reductase
X-ray structure of Escherichia coli dihydrofolate reductase in complex with trimethoprim
 0.77 36.13 0.97 3-158 X-ray 1.90 monomer 1 x NDP, 1 x TOP BLAST 0.39
7f3b.1.A
Dihydrofolate reductase
cocrystallization of Escherichia coli dihydrofolate reductase (DHFR) and its pyrrolo[3,2-f]quinazoline inhibitor.
 0.71 36.13 0.97 3-158 X-ray 2.81 monomer 1 x D4C BLAST 0.39
5uih.1.A
Dihydrofolate reductase
structure of DHFR with bound phenformin and NADP
 0.74 36.13 0.97 3-158 X-ray 1.65 monomer 1 x 8CV, 1 x NAP BLAST 0.39
4or7.1.A
Dihydrofolate reductase
Klebsiella pneumoniae dihydrofolate reductase complexed with NADPH and 6-ethyl-5-{3-[3-(pyrimidin-5-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine
 0.78 35.26 0.98 2-158 X-ray 1.76 monomer 1 x NAP, 1 x 25U HHblits 0.39
4osg.1.A
Dihydrofolate reductase
Klebsiella pneumoniae complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxyl-5-(pyridine-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)
 0.77 35.26 0.98 2-158 X-ray 2.70 monomer 1 x NAP, 1 x 06U HHblits 0.39
4osg.2.A
Dihydrofolate reductase
Klebsiella pneumoniae complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxyl-5-(pyridine-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)
 0.77 35.26 0.98 2-158 X-ray 2.70 monomer 1 x NAP, 1 x 06U, 1 x CAC HHblits 0.39
4osg.3.A
Dihydrofolate reductase
Klebsiella pneumoniae complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxyl-5-(pyridine-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)
 0.77 35.26 0.98 2-158 X-ray 2.70 monomer 1 x NAP, 1 x 06U, 1 x CA HHblits 0.39
4osg.4.A
Dihydrofolate reductase
Klebsiella pneumoniae complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxyl-5-(pyridine-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)
 0.77 35.26 0.98 2-158 X-ray 2.70 monomer 1 x NAP, 1 x 06U, 1 x CAC HHblits 0.39
1dhj.1.A
DIHYDROFOLATE REDUCTASE
LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE
 0.74 36.13 0.97 3-158 X-ray 1.80 homo-dimer 2 x MTX, 1 x CA BLAST 0.39
1dhj.1.B
DIHYDROFOLATE REDUCTASE
LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE
 0.75 36.13 0.97 3-158 X-ray 1.80 homo-dimer 2 x MTX, 1 x CA BLAST 0.39
1rb2.1.A
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)
 0.75 36.13 0.97 3-158 X-ray 2.10 homo-dimer 2 x FOL, 2 x NAP BLAST 0.39
2inq.1.A
Dihydrofolate reductase
Neutron Crystal Structure of Escherichia coli Dihydrofolate Reductase Bound to the Anti-cancer drug, Methotrexate
 0.70 36.13 0.97 3-158 neutron diff. 2.20 monomer 1 x MT1 BLAST 0.39
1rh3.1.A
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM)
 0.77 36.13 0.97 3-158 X-ray 2.40 monomer 1 x MTX, 1 x NAP BLAST 0.39
3kfy.1.A
Dihydrofolate reductase
Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR
 0.77 36.13 0.97 3-158 X-ray 2.08 monomer 1 x NDP, 1 x JZM, 3 x CA BLAST 0.39
1rf7.1.A
DIHYDROFOLATE REDUCTASE
STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDROFOLATE
 0.75 36.13 0.97 3-158 X-ray 1.80 monomer 1 x MN, 2 x DHF BLAST 0.39
3r33.1.A
Dihydrofolate reductase
Evidence for dynamic motion in proteins as a mechanism for ligand dissociation
 0.77 36.13 0.97 3-158 X-ray 2.09 monomer 1 x 6ME, 1 x NDP, 16 x CA BLAST 0.39
1rg7.1.A
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE
 0.72 36.13 0.97 3-158 X-ray 2.00 monomer 1 x MTX BLAST 0.39
4p68.1.A
Dihydrofolate reductase
Electrostatics of Active Site Microenvironments for E. coli DHFR
 0.77 35.48 0.97 3-158 X-ray 2.26 monomer 1 x MTX, 1 x NAP, 1 x CA BLAST 0.39
7mqp.1.A
Dihydrofolate reductase
E. coli dihydrofolate reductase complexed with 4'-chloro-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-[1,1'-biphenyl]-4-carboxamide (UCP1228)
 0.72 36.13 0.97 3-158 X-ray 2.10 homo-dimer 2 x ZM4 BLAST 0.39
4qlg.1.A
Dihydrofolate reductase
Crystal structure of I14V DHFR mutant complexed with folate and NADP+
 0.75 35.48 0.97 3-158 X-ray 1.50 monomer 1 x FOL, 1 x NAP BLAST 0.39
9c87.1.G
Dihydrofolate reductase
Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Linear-Degron DHFR-ssrA Substrate Bound with MTX
 0.65 36.13 0.97 3-158 EM 0.00 hetero-6-1-14-mer 3 x ATP, 4 x MG, 3 x ADP, 1 x MTX BLAST 0.39
8v9r.1.G
Dihydrofolate reductase
Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Branched-Degron DHFR-ssrA Substrate Bound with MTX
 0.73 36.13 0.97 3-158 EM 0.00 hetero-6-1-14-mer 3 x ATP, 4 x MG, 3 x ADP, 1 x MTX BLAST 0.39
4p68.1.A
Dihydrofolate reductase
Electrostatics of Active Site Microenvironments for E. coli DHFR
 0.79 33.97 0.98 2-158 X-ray 2.26 monomer 1 x MTX, 1 x NAP, 1 x CA HHblits 0.39
4p66.1.A
Dihydrofolate reductase
Electrostatics of Active Site Microenvironments of E. coli DHFR
 0.78 35.48 0.97 3-158 X-ray 1.84 monomer 1 x MTX, 1 x NAP, 1 x CA BLAST 0.39
4or7.1.A
Dihydrofolate reductase
Klebsiella pneumoniae dihydrofolate reductase complexed with NADPH and 6-ethyl-5-{3-[3-(pyrimidin-5-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine
 0.77 36.77 0.97 3-158 X-ray 1.76 monomer 1 x NAP, 1 x 25U BLAST 0.39
4osg.1.A
Dihydrofolate reductase
Klebsiella pneumoniae complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxyl-5-(pyridine-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)
 0.76 36.77 0.97 3-158 X-ray 2.70 monomer 1 x NAP, 1 x 06U BLAST 0.39
4osg.2.A
Dihydrofolate reductase
Klebsiella pneumoniae complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxyl-5-(pyridine-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)
 0.76 36.77 0.97 3-158 X-ray 2.70 monomer 1 x NAP, 1 x 06U, 1 x CAC BLAST 0.39
4osg.3.A
Dihydrofolate reductase
Klebsiella pneumoniae complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxyl-5-(pyridine-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)
 0.76 36.77 0.97 3-158 X-ray 2.70 monomer 1 x NAP, 1 x 06U, 1 x CA BLAST 0.39
4osg.4.A
Dihydrofolate reductase
Klebsiella pneumoniae complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxyl-5-(pyridine-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)
 0.75 36.77 0.97 3-158 X-ray 2.70 monomer 1 x NAP, 1 x 06U, 1 x CAC BLAST 0.39
4p66.1.A
Dihydrofolate reductase
Electrostatics of Active Site Microenvironments of E. coli DHFR
 0.79 33.97 0.98 2-158 X-ray 1.84 monomer 1 x MTX, 1 x NAP, 1 x CA HHblits 0.39
5cc9.1.A
Dihydrofolate reductase
L28F E.coli dihydrofolate reductase complexed with 5,10-dideazatetrahydrofolate and oxidized nicotinamide adenine dinucleotide phosphate
 0.75 33.97 0.98 2-158 X-ray 1.20 monomer 1 x NAP, 1 x DDF HHblits 0.39
5w3q.1.A
Dihydrofolate reductase
L28F E.coli DHFR in complex with NADPH
 0.79 33.97 0.98 2-158 X-ray 1.40 monomer 1 x NDP, 1 x CA HHblits 0.39
3ql0.1.A
Dihydrofolate reductase
Crystal structure of N23PP/S148A mutant of E. coli dihydrofolate reductase
 0.78 34.62 0.98 2-158 X-ray 1.60 monomer 1 x FOL, 1 x NAP HHblits 0.39
4qle.1.A
Dihydrofolate reductase
Crystal structure of I14A DHFR mutant complexed with folate and NADP+
 0.77 33.97 0.98 2-158 X-ray 1.35 monomer 1 x FOL, 1 x NAP HHblits 0.39
1dra.1.A
DIHYDROFOLATE REDUCTASE
CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING
 0.75 33.97 0.98 2-158 X-ray 1.90 homo-dimer 2 x MTX, 1 x CA HHblits 0.39
1dra.1.B
DIHYDROFOLATE REDUCTASE
CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING
 0.76 33.97 0.98 2-158 X-ray 1.90 homo-dimer 2 x MTX, 1 x CA HHblits 0.39
5cc9.1.A
Dihydrofolate reductase
L28F E.coli dihydrofolate reductase complexed with 5,10-dideazatetrahydrofolate and oxidized nicotinamide adenine dinucleotide phosphate
 0.74 35.48 0.97 3-158 X-ray 1.20 monomer 1 x NAP, 1 x DDF BLAST 0.39
5w3q.1.A
Dihydrofolate reductase
L28F E.coli DHFR in complex with NADPH
 0.78 35.48 0.97 3-158 X-ray 1.40 monomer 1 x NDP, 1 x CA BLAST 0.39
3ql0.1.A
Dihydrofolate reductase
Crystal structure of N23PP/S148A mutant of E. coli dihydrofolate reductase
 0.77 36.13 0.97 3-158 X-ray 1.60 monomer 1 x FOL, 1 x NAP BLAST 0.39
6xg4.1.A
Dihydrofolate reductase
X-ray structure of Escherichia coli dihydrofolate reductase L28R mutant in complex with trimethoprim
 0.79 33.97 0.98 2-158 X-ray 2.10 monomer 1 x NDP, 1 x TOP HHblits 0.39
5uii.1.A
Dihydrofolate reductase
structure of DHFR with bound buformin and NADP
 0.76 34.84 0.97 3-158 X-ray 1.35 monomer 1 x NAP, 1 x CA, 1 x BFR HHblits 0.39
4qle.1.A
Dihydrofolate reductase
Crystal structure of I14A DHFR mutant complexed with folate and NADP+
 0.76 35.48 0.97 3-158 X-ray 1.35 monomer 1 x FOL, 1 x NAP BLAST 0.39
1dra.1.A
DIHYDROFOLATE REDUCTASE
CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING
 0.74 35.48 0.97 3-158 X-ray 1.90 homo-dimer 2 x MTX, 1 x CA BLAST 0.39
1dra.1.B
DIHYDROFOLATE REDUCTASE
CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING
 0.75 35.48 0.97 3-158 X-ray 1.90 homo-dimer 2 x MTX, 1 x CA BLAST 0.39
1dhi.1.A
DIHYDROFOLATE REDUCTASE
LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE
 0.75 33.97 0.98 2-158 X-ray 1.90 homo-dimer 2 x MTX, 1 x CA HHblits 0.39
1dhi.1.B
DIHYDROFOLATE REDUCTASE
LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE
 0.76 33.97 0.98 2-158 X-ray 1.90 homo-dimer 2 x MTX, 1 x CA HHblits 0.39
3ia4.1.A
Dihydrofolate reductase
Moritella profunda dihydrofolate reductase (DHFR) in complex with NADPH and methotrexate (MTX)
 0.74 42.00 0.94 1-152 X-ray 1.70 monomer 1 x NDP, 1 x MTX BLAST 0.42
3ia5.1.A
Dihydrofolate reductase
Moritella profunda dihydrofolate reductase (DHFR)
 0.71 42.00 0.94 1-152 X-ray 2.10 monomer BLAST 0.42
6xg4.1.A
Dihydrofolate reductase
X-ray structure of Escherichia coli dihydrofolate reductase L28R mutant in complex with trimethoprim
 0.78 35.48 0.97 3-158 X-ray 2.10 monomer 1 x NDP, 1 x TOP BLAST 0.39
4qlf.1.A
Dihydrofolate reductase
Crystal structure of I14G DHFR mutant complexed with folate and NADP+
 0.73 33.97 0.98 2-158 X-ray 1.44 monomer 1 x FOL, 1 x NAP HHblits 0.38
8vz4.1.A
Dihydrofolate reductase
L54G Mutant of E. coli Dihydrofolate Reductase Complexed with Nicotinamide Adenine Dinucleotide Phosphate (oxidized form)
 0.75 33.97 0.98 2-158 X-ray 1.25 homo-dimer 2 x NAP HHblits 0.38
1dhi.1.A
DIHYDROFOLATE REDUCTASE
LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE
 0.74 35.48 0.97 3-158 X-ray 1.90 homo-dimer 2 x MTX, 1 x CA BLAST 0.39
1dhi.1.B
DIHYDROFOLATE REDUCTASE
LONG-RANGE STRUCTURAL EFFECTS IN A SECOND-SITE REVERTANT OF A MUTANT DIHYDROFOLATE REDUCTASE
 0.75 35.48 0.97 3-158 X-ray 1.90 homo-dimer 2 x MTX, 1 x CA BLAST 0.39
9c87.1.G
Dihydrofolate reductase
Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Linear-Degron DHFR-ssrA Substrate Bound with MTX
 0.66 34.84 0.97 3-158 EM 0.00 hetero-6-1-14-mer 3 x ATP, 4 x MG, 3 x ADP, 1 x MTX HHblits 0.39
4qlf.1.A
Dihydrofolate reductase
Crystal structure of I14G DHFR mutant complexed with folate and NADP+
 0.72 35.48 0.97 3-158 X-ray 1.44 monomer 1 x FOL, 1 x NAP BLAST 0.39
8vz4.1.A
Dihydrofolate reductase
L54G Mutant of E. coli Dihydrofolate Reductase Complexed with Nicotinamide Adenine Dinucleotide Phosphate (oxidized form)
 0.74 35.48 0.97 3-158 X-ray 1.25 homo-dimer 2 x NAP BLAST 0.39
1drb.1.A
DIHYDROFOLATE REDUCTASE
CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING
 0.75 33.97 0.98 2-158 X-ray 1.96 homo-dimer 2 x MTX, 1 x CA HHblits 0.38
1drb.1.B
DIHYDROFOLATE REDUCTASE
CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING
 0.76 33.97 0.98 2-158 X-ray 1.96 homo-dimer 2 x MTX, 1 x CA HHblits 0.38
2drc.1.A
DIHYDROFOLATE REDUCTASE
INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS
 0.75 33.97 0.98 2-158 X-ray 1.90 homo-dimer 2 x MTX, 1 x CA HHblits 0.38
2drc.1.B
DIHYDROFOLATE REDUCTASE
INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS
 0.77 33.97 0.98 2-158 X-ray 1.90 homo-dimer 2 x MTX, 1 x CA HHblits 0.38
1drb.1.A
DIHYDROFOLATE REDUCTASE
CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING
 0.74 35.48 0.97 3-158 X-ray 1.96 homo-dimer 2 x MTX, 1 x CA BLAST 0.39
1drb.1.B
DIHYDROFOLATE REDUCTASE
CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING
 0.75 35.48 0.97 3-158 X-ray 1.96 homo-dimer 2 x MTX, 1 x CA BLAST 0.39
2drc.1.A
DIHYDROFOLATE REDUCTASE
INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS
 0.74 35.48 0.97 3-158 X-ray 1.90 homo-dimer 2 x MTX, 1 x CA BLAST 0.39
2drc.1.B
DIHYDROFOLATE REDUCTASE
INVESTIGATION OF THE FUNCTIONAL ROLE OF TRYPTOPHAN-22 IN ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE BY SITE-DIRECTED MUTAGENESIS
 0.76 35.48 0.97 3-158 X-ray 1.90 homo-dimer 2 x MTX, 1 x CA BLAST 0.39
8f09.1.A
Dihydrofolate reductase
Crystal structure of a trimethoprim-resistant dihydrofolate reductase (DHFR) enzyme from an uncultured soil bacterium
 0.72 37.25 0.96 1-153 X-ray 2.45 monomer BLAST 0.40
8f09.2.A
Dihydrofolate reductase
Crystal structure of a trimethoprim-resistant dihydrofolate reductase (DHFR) enzyme from an uncultured soil bacterium
 0.72 37.25 0.96 1-153 X-ray 2.45 monomer BLAST 0.40
4gh8.1.A
Dihydrofolate reductase
Crystal structure of a 'humanized' E. coli dihydrofolate reductase
 0.75 35.71 0.97 3-157 X-ray 1.85 monomer 1 x MTX, 1 x NDP, 1 x CA BLAST 0.39
4gh8.1.A
Dihydrofolate reductase
Crystal structure of a 'humanized' E. coli dihydrofolate reductase
 0.76 34.19 0.97 2-157 X-ray 1.85 monomer 1 x MTX, 1 x NDP, 1 x CA HHblits 0.38
4ky4.3.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of non-classical TS inhibitor 2 in complex with Toxoplasma gondii TS-DHFR
 0.70 32.91 0.99 1-158 X-ray 2.79 homo-dimer 2 x UMP, 2 x 04J, 2 x NDP, 2 x 1UE HHblits 0.37
4eck.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal Structure of the Toxoplasma gondii TS-DHFR
 0.66 32.91 0.99 1-158 X-ray 3.52 homo-dimer 2 x UMP, 2 x CB3, 2 x FOL, 2 x NDP HHblits 0.37
4eck.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal Structure of the Toxoplasma gondii TS-DHFR
 0.67 32.91 0.99 1-158 X-ray 3.52 homo-dimer 2 x UMP, 2 x CB3, 2 x FOL, 2 x NDP HHblits 0.37
7fgx.2.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with P39, NADPH and dUMP
 0.72 32.91 0.99 1-158 X-ray 2.05 homo-dimer 2 x NDP, 2 x 4RI, 2 x UMP HHblits 0.37
7fgy.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with P40, NADPH and dUMP
 0.71 32.91 0.99 1-158 X-ray 2.67 homo-dimer 2 x NDP, 2 x 4TS, 2 x UMP HHblits 0.37
7fgy.2.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with P40, NADPH and dUMP
 0.71 32.91 0.99 1-158 X-ray 2.67 homo-dimer 2 x NDP, 2 x 4TS, 2 x UMP HHblits 0.37
1dis.1.A
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEX WITH BRODIMOPRIM-4,6-DICARBOXYLATE
 0.76 34.19 0.97 3-158 NMR 0.00 monomer 1 x BDM HHblits 0.38
2l28.1.A
Dihydrofolate reductase
Solution structure of lactobacillus casei dihydrofolate reductase apo-form, 25 conformers
 0.65 34.19 0.97 3-158 NMR 0.00 monomer HHblits 0.38
2lf1.1.A
Dihydrofolate reductase
Solution structure of L. casei dihydrofolate reductase complexed with NADPH, 30 structures
 0.69 34.19 0.97 3-158 NMR 0.00 monomer 1 x NDP HHblits 0.38
2hm9.1.A
Dihydrofolate reductase
Solution structure of dihydrofolate reductase complexed with trimethoprim, 33 structures
 0.68 34.19 0.97 3-158 NMR 0.00 monomer 1 x TRR HHblits 0.38
1lud.1.A
DIHYDROFOLATE REDUCTASE
SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES
 0.72 34.19 0.97 3-158 NMR 0.00 monomer 1 x NDP, 1 x TRR HHblits 0.38
1bzf.1.A
DIHYDROFOLATE REDUCTASE
NMR SOLUTION STRUCTURE AND DYNAMICS OF THE COMPLEX OF LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE WITH THE NEW LIPOPHILIC ANTIFOLATE DRUG TRIMETREXATE, 22 STRUCTURES
 0.69 34.19 0.97 3-158 NMR 0.00 monomer 1 x TMQ HHblits 0.38
1ao8.1.A
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE, NMR, 21 STRUCTURES
 0.71 34.19 0.97 3-158 NMR 0.00 monomer 1 x MTX HHblits 0.38
2hqp.1.A
Dihydrofolate reductase
Solution structure of L.casei dihydrofolate reductase complexed with NADPH, 32 structures
 0.64 34.19 0.97 3-158 NMR 0.00 monomer 1 x NDP HHblits 0.38
8dae.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase 1
Arabidopsis thaliana bifunctional dihydrofolate reductase-thymidylate synthase
 0.64 37.25 0.96 2-159 X-ray 2.00 homo-tetramer BLAST 0.39
2zza.1.A
Dihydrofolate reductase
Moritella profunda Dihydrofolate reductase complex with NADP+ and Folate
 0.73 41.89 0.93 3-152 X-ray 2.00 monomer 1 x NAP, 1 x FOL BLAST 0.42
3dfr.1.A
DIHYDROFOLATE REDUCTASE
CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE
 0.76 33.55 0.97 3-158 X-ray 1.70 monomer 1 x NDP, 1 x MTX HHblits 0.38
4eil.4.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal Structure of the loop truncated Toxoplasma gondii TS-DHFR
 0.71 33.12 0.99 2-158 X-ray 2.20 homo-dimer 2 x UMP, 2 x CB3, 2 x FOL, 2 x NDP HHblits 0.37
4eil.2.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal Structure of the loop truncated Toxoplasma gondii TS-DHFR
 0.69 33.12 0.99 2-158 X-ray 2.20 homo-dimer 2 x UMP, 2 x CB3, 2 x FOL, 2 x NDP HHblits 0.37
3k45.1.A
Dihydrofolate reductase
Alternate Binding Modes Observed for the E- and Z-isomers of 2,4-Diaminofuro[2,3d]pyrimidines as Ternary Complexes with NADPH and Mouse Dihydrofolate Reductase
 0.71 29.56 1.00 1-159 X-ray 1.60 monomer 1 x NDP, 1 x 51P HHblits 0.35
4ixf.1.A
Dihydrofolate reductase
pcDHFR-269 F69N variant
 0.68 29.75 0.99 1-158 X-ray 1.70 monomer 1 x NDP, 1 x IXF HHblits 0.36
1vj3.1.A
DIHYDROFOLATE REDUCTASE
STRUCTURAL STUDIES ON BIO-ACTIVE COMPOUNDS. CRYSTAL STRUCTURE AND MOLECULAR MODELING STUDIES ON THE PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COFACTOR COMPLEX WITH TAB, A HIGHLY SELECTIVE ANTIFOLATE.
 0.67 29.75 0.99 1-158 X-ray 2.10 monomer 1 x NDP, 1 x TAB HHblits 0.36
3f8y.1.A
Dihydrofolate reductase
Correlations of Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes
 0.72 0.00 28.93 1.00 1-159 X-ray 1.45 monomer 1 x DH1, 1 x NDP HHblits 0.35
3ghv.1.A
Dihydrofolate reductase
Human dihydrofolate reductase Q35K/N64F double mutant inhibitor complex
 0.71 0.00 28.93 1.00 1-159 X-ray 1.30 monomer 1 x GHC, 1 x NDP HHblits 0.35
3d84.1.A
Dihydrofolate reductase
Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with NADPH and a Ternary Complex with the Potent and Selective Inhibitor 2.4-Diamino-6-(-2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine
 0.70 28.93 1.00 1-159 X-ray 1.90 monomer 1 x NDP HHblits 0.35
3i3r.1.A
Dihydrofolate reductase/thymidylate synthase
X-ray structure dihydrofolate reductase/thymidylate synthase from babesia bovis at 2.35A resolution
 0.70 32.90 0.97 1-159 X-ray 2.35 homo-dimer HHblits 0.37
3nrr.1.A
Dihydrofolate reductase-thymidylate synthase
Co-crystal structure of dihydrofolate reductase-thymidylate synthase from Babesia bovis with dUMP, Raltitrexed and NADP
 0.72 32.90 0.97 1-159 X-ray 1.80 homo-dimer 2 x NAP, 4 x D16, 2 x UMP HHblits 0.37
3l3r.1.A
Dihydrofolate reductase
Structural, Computational and Kinetic Data for Antifolate Interactions Against Pneumocystis jirovecii, Pneumocystis carinii and Human Dihydrofolate Reductase and Their Active Site Mutants
 0.71 0.00 28.93 1.00 1-159 X-ray 2.00 monomer 1 x OAG, 1 x NDP HHblits 0.35
2w3m.1.A
DIHYDROFOLATE REDUCTASE
HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND FOLATE
 0.70 0.00 28.30 1.00 1-159 X-ray 1.60 monomer 1 x NDP, 1 x FOL HHblits 0.35
6dav.2.A
Dihydrofolate reductase
Crystal Structure of Human DHFR complexed with NADP and N10formyltetrahydrofolate
 0.71 0.00 28.30 1.00 1-159 X-ray 1.55 monomer 1 x NAP, 1 x G3V HHblits 0.35
3fs6.1.A
Dihydrofolate reductase
Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes
 0.71 0.00 28.30 1.00 1-159 X-ray 1.23 monomer 1 x DH1, 1 x NDP HHblits 0.35
3gyf.1.A
Dihydrofolate reductase
Human DHFR with Z-isomer in Orthorhombic lattice
 0.71 0.00 28.30 1.00 1-159 X-ray 1.70 monomer 1 x 51P, 1 x NDP HHblits 0.35
4m6l.1.A
Dihydrofolate reductase
Crystal structure of human dihydrofolate reductase (DHFR) bound to NADP+ and 5,10-dideazatetrahydrofolic acid
 0.71 0.00 28.30 1.00 1-159 X-ray 1.70 monomer 1 x 21V, 1 x NAP, 1 x DTT HHblits 0.35
4m6j.1.A
Dihydrofolate reductase
Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH
 0.72 28.30 1.00 1-159 X-ray 1.20 monomer 1 x NDP HHblits 0.35
7xi7.1.A
Dihydrofolate reductase
Human dihydrofolate reductase complexed with P39
 0.70 28.30 1.00 1-159 X-ray 1.65 monomer 1 x 4RI HHblits 0.35
1mvt.1.A
Dihydrofolate Reductase
Analysis of Two Polymorphic Forms of a Pyrido[2,3-d]pyrimidine N9-C10 Reverse-Bridge Antifolate Binary Complex with Human Dihydrofolate Reductase
 0.70 28.30 1.00 1-159 X-ray 1.80 monomer 1 x DTM HHblits 0.35
5sd7.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-735
 0.71 28.30 1.00 1-159 X-ray 1.80 monomer 1 x NAP, 1 x I0E HHblits 0.35
6vcj.1.A
Dihydrofolate reductase
Crystal structure of hsDHFR in complex with NADP+, DAP, and R-naproxen
 0.71 28.30 1.00 1-159 X-ray 2.34 monomer 1 x LG3, 1 x NPX, 1 x NAP, 1 x FOL HHblits 0.35
7ese.1.A
Dihydrofolate reductase
The Crystal Structure of human DHFR from Biortus
 0.69 28.30 1.00 1-159 X-ray 1.85 monomer 1 x NAP, 1 x FOL HHblits 0.35
4ixg.1.A
Dihydrofolate reductase
pcDHFR-268-K37S-N69F variant
 0.67 29.11 0.99 1-158 X-ray 1.70 monomer 1 x NDP, 1 x IXG HHblits 0.36
1u70.1.A
Dihydrofolate reductase
Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase
 0.69 28.93 1.00 1-159 X-ray 2.50 monomer 1 x MTX, 1 x NDP HHblits 0.35
3f8z.1.A
Dihydrofolate reductase
Human Dihydrofolate Reductase Structural Data with Active Site Mutant Enzyme Complexes
 0.71 28.30 1.00 1-159 X-ray 2.01 monomer 1 x DH1, 1 x NDP HHblits 0.35
2fzh.1.A
Dihydrofolate reductase
New Insights into Dihydrofolate Reductase Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives
 0.67 29.11 0.99 1-158 X-ray 2.10 monomer 1 x NDP, 1 x DH1 HHblits 0.36
1cd2.1.A
DIHYDROFOLATE REDUCTASE
LIGAND INDUCED CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURES OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEXES WITH FOLATE AND NADP+
 0.67 29.11 0.99 1-158 X-ray 2.20 monomer 1 x NAP, 1 x FOL HHblits 0.36
3cd2.1.A
DIHYDROFOLATE REDUCTASE
LIGAND INDUCED CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURES OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEXES WITH FOLATE AND NADP+
 0.67 29.11 0.99 1-158 X-ray 2.50 monomer 1 x NAP, 1 x MTX HHblits 0.36
4ixe.1.A
Dihydrofolate reductase
pcDHFR-NADPH-270
 0.69 29.11 0.99 1-158 X-ray 1.54 monomer 1 x IXE, 1 x NDP HHblits 0.36
4qjz.1.A
Dihydrofolate reductase
Pneumocystis carinii dihydrofolate reductase ternary complex with NADPH and the inhibitor 24, (N~6~-METHYL-N~6~-(NAPHTHALEN-1-YL)PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE)
 0.69 29.11 0.99 1-158 X-ray 1.61 monomer 1 x 33M, 1 x NDP HHblits 0.36
1e26.1.A
DIHYDROFOLATE REDUCTASE
Design, Synthesis and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent.
 0.68 29.11 0.99 1-158 X-ray 2.00 monomer 1 x NAP, 1 x GPB HHblits 0.36
4cd2.1.A
DIHYDROFOLATE REDUCTASE
LIGAND INDUCED CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURES OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEXES WITH FOLATE AND NADP+
 0.64 29.11 0.99 1-158 X-ray 2.00 monomer 1 x FOL HHblits 0.36
1s3y.1.A
Dihydrofolate reductase
Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
 0.66 29.11 0.99 1-158 X-ray 2.25 monomer 1 x NAP, 1 x TQT HHblits 0.36
1klk.1.A
Dihydrofolate reductase
CRYSTAL STRUCTURE OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE TERNARY COMPLEX WITH PT653 AND NADPH
 0.67 29.11 0.99 1-158 X-ray 2.30 monomer 1 x PMD, 1 x NDP HHblits 0.36
3nxo.1.A
Dihydrofolate reductase
Perferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for the E- and Z-isomers of a Series of 5-Substituted 2,4-Diaminofuro[2,3-d]pyrimidines as Ternary Complexes with NADPH and Human Dihydrofolate Reductase
 0.71 28.30 1.00 1-159 X-ray 1.35 monomer 1 x D2B, 1 x NDP HHblits 0.35
3ghc.1.A
Dihydrofolate reductase
Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-amino-4-oxo-5-substituted-6-thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agenst
 0.71 28.30 1.00 1-159 X-ray 1.30 monomer 1 x GHC, 1 x NDP HHblits 0.35
1hfp.1.A
DIHYDROFOLATE REDUCTASE
COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE
 0.71 28.30 1.00 1-159 X-ray 2.10 monomer 1 x NDP, 1 x MOT HHblits 0.35
1dlr.1.A
DIHYDROFOLATE REDUCTASE
METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE REDUCTASE WITH SUBSTITUTION OF LEUCINE 22: KINETICS, CRYSTALLOGRAPHY AND POTENTIAL AS SELECTABLE MARKERS
 0.71 27.67 1.00 1-159 X-ray 2.30 monomer 1 x NDP, 1 x MXA HHblits 0.35
3n0h.1.A
Dihydrofolate reductase
hDHFR double mutant Q35S/N64F Trimethoprim Binary Complex
 0.70 28.30 1.00 1-159 X-ray 1.92 monomer 2 x TOP HHblits 0.35
8dae.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase 1
Arabidopsis thaliana bifunctional dihydrofolate reductase-thymidylate synthase
 0.72 33.97 0.98 1-158 X-ray 2.00 homo-tetramer HHblits 0.36
1hfq.1.A
DIHYDROFOLATE REDUCTASE
COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE
 0.71 28.30 1.00 1-159 X-ray 2.10 monomer 1 x NDP, 1 x MOT HHblits 0.35
1dls.1.A
DIHYDROFOLATE REDUCTASE
METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE REDUCTASE WITH SUBSTITUTION OF LEUCINE 22: KINETICS, CRYSTALLOGRAPHY AND POTENTIAL AS SELECTABLE MARKERS
 0.71 27.67 1.00 1-159 X-ray 2.30 monomer 1 x NDP, 1 x MTX HHblits 0.35
3f91.1.A
Dihydrofolate reductase
Structural Data for Human Active Site Mutant Enzyme Complexes
 0.71 27.67 1.00 1-159 X-ray 1.90 monomer 1 x DH1, 1 x NDP HHblits 0.35
1pd8.1.A
Dihydrofolate reductase
Analysis of Three Crystal Structure Determinations of a 5-Methyl-6-N-Methylanilino Pyridopyrimidine Antifolate Complex with Human Dihydrofolate Reductase
 0.71 28.48 0.99 2-159 X-ray 2.10 monomer 1 x NDP, 1 x CO4 HHblits 0.35
1pd9.1.A
Dihydrofolate reductase
Analysis of Three Crystal Structure Determinations of a 5-Methyl-6-N-Methylanilino Pyridopyrimidine antifolate Complex with Human Dihydrofolate Reductase
 0.71 28.48 0.99 2-159 X-ray 2.20 monomer 1 x CO4 HHblits 0.35
1s3v.1.A
Dihydrofolate reductase
Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
 0.70 28.48 0.99 2-159 X-ray 1.80 monomer 1 x TQD HHblits 0.35
4keb.1.A
Dihydrofolate reductase
Human dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5-(isoquin-5-yl)phenyl]but-1-yn-1-yl}6-ethylpyrimidine-2,4-diamine
 0.70 28.48 0.99 2-159 X-ray 1.45 monomer 1 x NDP, 1 x 1QZ HHblits 0.35
4kd7.2.A
Dihydrofolate reductase
Human dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5(pyridine-4-yl)phenyl]prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4-diamine
 0.70 28.48 0.99 2-159 X-ray 2.72 monomer 1 x NDP, 1 x 9DR HHblits 0.35
1dhf.1.A
DIHYDROFOLATE REDUCTASE
CRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE
 0.70 28.48 0.99 2-159 X-ray 2.30 homo-dimer 2 x FOL HHblits 0.35
1dhf.1.B
DIHYDROFOLATE REDUCTASE
CRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE
 0.70 28.48 0.99 2-159 X-ray 2.30 homo-dimer 2 x FOL HHblits 0.35
5hsr.1.A
Dihydrofolate reductase
Fluorine substituted 5-methyl-6-(3',4'-difluoromethoxyphenythio)thieno[2,3-d]pyrimidine-2,4-diamine
 0.71 28.48 0.99 2-159 X-ray 1.21 monomer 1 x NDP, 2 x 63Y HHblits 0.35
1pdb.1.A
Dihydrofolate reductase
Analysis of Three Crystal Structure Determinations of a 5-Methyl-6-N-Methylanilino Pyridopyrimidine Antifolate Complex with Human Dihydrofolate Reductase
 0.69 28.48 0.99 2-159 X-ray 2.20 monomer HHblits 0.35
4g95.1.A
Dihydrofolate reductase
hDHFR-OAG binary complex
 0.71 28.48 0.99 2-159 X-ray 1.35 monomer 1 x OAG HHblits 0.35
3s7a.1.A
Dihydrofolate reductase
Human dihydrofolate reductase binary complex with PT684
 0.70 28.48 0.99 2-159 X-ray 1.80 monomer 1 x 684 HHblits 0.35
4keb.2.A
Dihydrofolate reductase
Human dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5-(isoquin-5-yl)phenyl]but-1-yn-1-yl}6-ethylpyrimidine-2,4-diamine
 0.70 28.48 0.99 2-159 X-ray 1.45 monomer 1 x NDP, 1 x FOL HHblits 0.35
1drf.1.A
DIHYDROFOLATE REDUCTASE
CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE
 0.71 28.48 0.99 2-159 X-ray 2.00 monomer 1 x FOL HHblits 0.35
1ohk.1.A
DIHYDROFOLATE REDUCTASE
HUMAN DIHYDROFOLATE REDUCTASE, ORTHORHOMBIC (P21 21 21) CRYSTAL FORM
 0.68 28.48 0.99 2-159 X-ray 2.50 monomer 1 x NDP, 1 x COP HHblits 0.35
1ohj.1.A
DIHYDROFOLATE REDUCTASE
HUMAN DIHYDROFOLATE REDUCTASE, MONOCLINIC (P21) CRYSTAL FORM
 0.70 28.48 0.99 2-159 X-ray 2.50 monomer 1 x NDP, 1 x COP HHblits 0.35
1kmv.1.A
DIHYDROFOLATE REDUCTASE
HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE (SRI-9662), A LIPOPHILIC ANTIFOLATE
 0.70 28.48 0.99 2-159 X-ray 1.05 monomer 1 x LII, 1 x NDP HHblits 0.35
1yho.1.A
Dihydrofolate reductase
Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures
 0.64 28.48 0.99 2-159 NMR 0.00 monomer 1 x NDP, 1 x TRR HHblits 0.35
1u71.1.A
Dihydrofolate reductase
Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH
 0.71 27.67 1.00 1-159 X-ray 2.20 monomer 1 x MXA HHblits 0.35
3eig.1.A
Dihydrofolate reductase
Crystal structure of a methotrexate-resistant mutant of human dihydrofolate reductase
 0.69 28.48 0.99 2-159 X-ray 1.70 monomer 1 x MTX, 1 x CD HHblits 0.35
1ia2.2.A
DIHYDROFOLATE REDUCTASE
Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) and 5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE (GW578)
 0.68 30.57 0.99 1-158 X-ray 1.82 monomer 1 x NDP, 1 x TQ4, 1 x MES HHblits 0.36
1ia2.1.A
DIHYDROFOLATE REDUCTASE
Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) and 5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE (GW578)
 0.66 30.57 0.99 1-158 X-ray 1.82 monomer 1 x NDP, 1 x TQ4, 1 x MES HHblits 0.36
3qlw.1.A
Putative uncharacterized protein CaJ7.0360
Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine (UCP120B)
 0.68 30.57 0.99 1-158 X-ray 2.50 monomer 1 x NDP, 1 x N22 HHblits 0.36
3qls.1.A
Putative uncharacterized protein CaJ7.0360
Candida albicans dihydrofolate reductase complexed with NADPH and 6-methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP115A)
 0.68 30.57 0.99 1-158 X-ray 1.73 monomer 1 x NDP, 1 x 55V, 1 x GLY HHblits 0.36
1dr1.2.B
DIHYDROFOLATE REDUCTASE
2.2 ANGSTROMS CRYSTAL STRUCTURE OF CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADP+ AND BIOPTERIN
 0.69 27.04 1.00 1-159 X-ray 2.20 homo-dimer 2 x CA, 2 x NAP, 2 x HBI HHblits 0.35
4h97.1.A
Dihydrofolate Reductase
Candida albicans dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5-(4-methylphenyl)phenyl]but-1-yn-1-yl}-6-methylpyrimidine-2,4-diamine (UCP111D4M)
 0.67 30.57 0.99 1-158 X-ray 2.20 monomer 1 x NDP, 1 x 53S HHblits 0.36
8e4f.1.A
Dihydrofolate reductase
Crystal structure of dihydrofolate reductase (DHFR) from the filarial nematode W. bancrofti in complex with NADPH and folate
 0.72 31.65 0.99 1-159 X-ray 2.47 monomer 1 x NAP, 1 x FOL HHblits 0.35
7zzx.1.A
Dihydrofolate reductase
Crystal structure of Candida auris DHFR in apo form
 0.64 27.22 0.99 1-159 X-ray 2.40 monomer HHblits 0.35
8a0z.1.A
Dihydrofolate reductase
Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and pyrimethamine
 0.67 27.22 0.99 1-159 X-ray 1.70 monomer 1 x NDP, 1 x CP6 HHblits 0.35
8a0z.2.A
Dihydrofolate reductase
Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and pyrimethamine
 0.68 27.22 0.99 1-159 X-ray 1.70 monomer 1 x NDP, 1 x CP6 HHblits 0.35
4g8z.1.A
Dihydrofolate reductase
pcDHFR K37S/F69N double mutant TMP NADPH ternary complex
 0.67 27.85 0.99 1-158 X-ray 1.75 monomer 1 x TOP, 1 x NDP HHblits 0.35
3irm.2.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH Cycloguanil
 0.65 31.01 0.99 1-158 X-ray 2.10 homo-dimer 2 x 1CY HHblits 0.35
3irn.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH NADPH AND Cycloguanil
 0.65 31.01 0.99 1-158 X-ray 2.60 homo-dimer 2 x 1CY, 2 x NDP HHblits 0.35
3irn.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH NADPH AND Cycloguanil
 0.66 31.01 0.99 1-158 X-ray 2.60 homo-dimer 2 x 1CY, 2 x NDP HHblits 0.35
3irn.2.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH NADPH AND Cycloguanil
 0.66 31.01 0.99 1-158 X-ray 2.60 homo-dimer 2 x 1CY, 2 x NDP HHblits 0.35
3irn.2.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH NADPH AND Cycloguanil
 0.64 31.01 0.99 1-158 X-ray 2.60 homo-dimer 2 x 1CY, 2 x NDP HHblits 0.35
3inv.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH NADPH, dUMP AND C-448 ANTIFOLATE
 0.66 31.01 0.99 1-158 X-ray 2.37 homo-dimer 2 x C50, 2 x NDP, 2 x UMP HHblits 0.35
8crh.1.A
Dihydrofolate reductase
Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and cycloguanil
 0.69 27.22 0.99 1-159 X-ray 1.30 homo-dimer 4 x VIL, 2 x NDP HHblits 0.35
8crh.1.B
Dihydrofolate reductase
Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and cycloguanil
 0.68 27.22 0.99 1-159 X-ray 1.30 homo-dimer 4 x VIL, 2 x NDP HHblits 0.35
8a0n.1.A
Dihydrofolate reductase
Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH
 0.67 27.22 0.99 1-159 X-ray 1.40 monomer 1 x NDP HHblits 0.35
3cl9.2.B
Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS)
Structure of bifunctional TcDHFR-TS in complex with MTX
 0.66 31.01 0.99 1-158 X-ray 3.30 homo-dimer 2 x NAP, 2 x MTX, 2 x UMP HHblits 0.35
3clb.2.A
DHFR-TS
Structure of bifunctional TcDHFR-TS in complex with TMQ
 0.65 31.01 0.99 1-158 X-ray 3.00 homo-dimer 2 x NAP, 2 x TMQ HHblits 0.35
3clb.1.A
DHFR-TS
Structure of bifunctional TcDHFR-TS in complex with TMQ
 0.68 31.01 0.99 1-158 X-ray 3.00 homo-dimer 2 x NAP, 2 x TMQ HHblits 0.35
3clb.1.B
DHFR-TS
Structure of bifunctional TcDHFR-TS in complex with TMQ
 0.67 31.01 0.99 1-158 X-ray 3.00 homo-dimer 2 x NAP, 2 x TMQ HHblits 0.35
2h2q.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate synthase
 0.63 31.01 0.99 1-158 X-ray 2.40 homo-dimer 2 x NAP, 2 x DU HHblits 0.35
4h95.1.A
Dihydrofolate Reductase
Candida albicans dihydrofolate reductase complexed with NADPH and 6-ethyl-5-{3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine (UCP1006)
 0.66 30.77 0.98 2-158 X-ray 2.60 monomer 1 x NDP, 1 x 06U HHblits 0.36
7k6c.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium abscessus ATCC 19977 / DSM 44196 with NADP and inhibitor P218
 0.76 28.85 0.98 1-159 X-ray 2.00 monomer 1 x NAP, 1 x MMV, 1 x CA HHblits 0.36
3hj3.1.A
Chain A, crystal structure of Dhfr
Crystal Structure of the ChTS-DHFR F207A Non-Active Site Mutant
 0.70 32.26 0.97 1-158 X-ray 2.70 homo-dimer 2 x UMP, 2 x CB3, 2 x MTX, 2 x NDP HHblits 0.36
2oip.1.A
Chain A, crystal structure of Dhfr
Crystal Structure of the S290G Active Site Mutant of TS-DHFR from Cryptosporidium hominis
 0.70 32.26 0.97 1-158 X-ray 2.80 homo-dimer 2 x UMP, 2 x CB3, 2 x MTX, 2 x NDP HHblits 0.36
1qzf.2.A
bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of DHFR-TS from Cryptosporidium hominis
 0.72 30.97 0.97 1-158 X-ray 2.80 homo-dimer 2 x UMP, 2 x CB3, 2 x FOL, 2 x NDP HHblits 0.36
6wep.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of TS-DHFR from Cryptosporidium hominis with Apo-TS site
 0.71 30.97 0.97 1-158 X-ray 2.79 homo-dimer 2 x NDP, 2 x MTX HHblits 0.36
3dl5.1.A
Dihydrofolate reductase, DHFR
Crystal Structure of the A287F Active Site Mutant of TS-DHFR from Cryptosporidium hominis
 0.71 30.97 0.97 1-158 X-ray 2.74 homo-dimer 2 x UMP, 2 x CB3, 2 x DHF, 2 x NDP HHblits 0.36
3dl6.1.A
Dihydrofolate reductase, DHFR
Crystal Structure of the A287F/S290G Active Site Mutant of TS-DHFR from Cryptosporidium hominis
 0.71 30.97 0.97 1-158 X-ray 3.25 homo-dimer 2 x UMP, 2 x CB3, 2 x DHF, 2 x NDP HHblits 0.36
3ro9.1.A
Strain CBS138 chromosome J complete sequence
Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)
 0.64 26.58 0.99 1-158 X-ray 2.60 monomer 1 x NDP, 1 x 06U HHblits 0.34
3qfx.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Trypanosoma brucei dihydrofolate reductase pyrimethamine complex
 0.65 26.42 1.00 1-159 X-ray 2.20 monomer 1 x NDP, 1 x CP6 HHblits 0.34
3rg9.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Trypanosoma brucei dihydrofolate reductase (TbDHFR) in complex with WR99210
 0.65 26.42 1.00 1-159 X-ray 2.00 monomer 1 x NDP, 1 x WRA HHblits 0.34
4h98.1.A
Dihydrofolate Reductase
Candida glabrata dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)
 0.64 26.58 0.99 1-158 X-ray 2.90 monomer 1 x NDP, 1 x 14Q HHblits 0.34
3qlx.2.A
Dihydrofolate reductase
Candida glabrata dihydrofolate reductase complexed with NADPH and 6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)pent-1-yn-1-yl]pyrimidine-2,4-diamine (UCP112A)
 0.64 26.58 0.99 1-158 X-ray 2.24 monomer 1 x NDP, 1 x QLR HHblits 0.34
2bla.1.A
DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE
SP21 double mutant P. vivax Dihydrofolate reductase in complex with pyrimethamine
 0.67 32.90 0.97 2-158 X-ray 2.50 monomer 1 x NDP, 1 x CP6, 1 x MES HHblits 0.36
2blc.1.A
DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE
SP21 double mutant P. vivax Dihydrofolate reductase in complex with des-chloropyrimethamine
 0.68 32.90 0.97 2-158 X-ray 2.25 monomer 1 x NDP, 1 x CP7, 1 x MES HHblits 0.36
6uww.1.A
Dihydrofolate reductase
Crystal structure of dihydrofolate reductase from Mycobacterium ulcerans with P218 inhibitor
 0.74 28.39 0.97 1-158 X-ray 0.92 monomer 1 x MMV, 1 x NAP HHblits 0.35
7km7.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001914, tetragonal crystal from
 0.74 28.39 0.97 1-158 X-ray 1.80 monomer 1 x NAP, 1 x WPD, 1 x BR HHblits 0.35
3dg8.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF670, NADPH, and dUMP
 0.68 0.00 28.21 0.98 2-159 X-ray 2.58 monomer 1 x RJ6, 1 x NDP, 1 x UMP HHblits 0.35
3dg8.2.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF670, NADPH, and dUMP
 0.68 0.00 28.21 0.98 2-159 X-ray 2.58 monomer 1 x RJ6, 1 x NDP, 1 x UMP HHblits 0.35
1j3k.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with WR99210, NADPH, and dUMP
 0.69 0.00 28.21 0.98 2-159 X-ray 2.10 monomer 2 x WRA, 2 x NDP, 2 x UMP HHblits 0.35
1j3k.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with WR99210, NADPH, and dUMP
 0.69 0.00 28.21 0.98 2-159 X-ray 2.10 monomer 2 x WRA, 2 x NDP, 2 x UMP HHblits 0.35
1dr1.2.B
DIHYDROFOLATE REDUCTASE
2.2 ANGSTROMS CRYSTAL STRUCTURE OF CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADP+ AND BIOPTERIN
 0.63 31.79 0.95 2-152 X-ray 2.20 homo-dimer 2 x CA, 2 x NAP, 2 x HBI BLAST 0.37
8ta1.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM907
 0.73 28.39 0.97 1-158 X-ray 1.50 monomer HHblits 0.35
7km9.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001913, tetragonal crystal from
 0.73 28.39 0.97 1-158 X-ray 1.95 monomer 1 x NAP, 1 x WPJ, 1 x BR HHblits 0.35
6uwq.1.A
Dihydrofolate reductase
Crystal structure of dihydrofolate reductase from Mycobacterium ulcerans with SDDC-0001565 inhibitor
 0.71 28.39 0.97 1-158 X-ray 1.50 monomer 1 x NAP, 1 x QKJ HHblits 0.35
3vco.1.A
Dihydrofolate reductase
Schistosoma mansoni Dihydrofolate reductase
 0.64 30.38 0.99 1-158 X-ray 1.95 monomer HHblits 0.34
1j3j.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Double mutant (C59R+S108N) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with pyrimethamine, NADPH, and dUMP
 0.68 0.00 28.21 0.98 2-159 X-ray 2.30 monomer 2 x CP6, 2 x NDP, 2 x UMP HHblits 0.35
1j3j.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Double mutant (C59R+S108N) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with pyrimethamine, NADPH, and dUMP
 0.68 0.00 28.21 0.98 2-159 X-ray 2.30 monomer 2 x CP6, 2 x NDP, 2 x UMP HHblits 0.35
6drs.1.A
Dihydrofolate reductase, putative
Dihydrofolate Reductase (DHFR) of Aspergillus flavus in complex with a small molecule inhibitor
 0.67 26.58 0.99 1-158 X-ray 2.00 monomer 1 x H8A, 1 x NAP HHblits 0.34
7k68.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001565
 0.73 28.39 0.97 1-158 X-ray 1.45 monomer 1 x NAP, 1 x QKJ HHblits 0.35
3dga.2.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF01302, NADPH, and dUMP
 0.69 0.00 28.21 0.98 2-159 X-ray 2.70 monomer 1 x RJ1, 1 x NDP, 1 x UMP HHblits 0.35
3dga.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF01302, NADPH, and dUMP
 0.68 0.00 28.21 0.98 2-159 X-ray 2.70 monomer 1 x RJ1, 1 x NDP, 1 x UMP HHblits 0.35
1j3i.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with WR99210, NADPH, and dUMP
 0.68 28.21 0.98 2-159 X-ray 2.33 hetero-2-2-mer 2 x WRA, 2 x NDP, 2 x UMP HHblits 0.35
1j3i.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with WR99210, NADPH, and dUMP
 0.69 28.21 0.98 2-159 X-ray 2.33 hetero-2-2-mer 2 x WRA, 2 x NDP, 2 x UMP HHblits 0.35
8wgm.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS V1/S, N51I+C59R+S108N+I164L) complexed with LA1, NADPH and dUMP
 0.69 28.39 0.97 2-158 X-ray 2.15 homo-dimer HHblits 0.35
8wgm.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS V1/S, N51I+C59R+S108N+I164L) complexed with LA1, NADPH and dUMP
 0.68 28.39 0.97 2-158 X-ray 2.15 homo-dimer HHblits 0.35
8jfb.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
V1/S quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with compound 4 (B21588), NADPH and dUMP
 0.68 28.39 0.97 2-158 X-ray 2.65 homo-dimer 2 x U86, 2 x NDP, 2 x UMP HHblits 0.35
8jfd.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
V1/S quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with compound 8 (B21594), NADPH and dUMP
 0.68 28.39 0.97 2-158 X-ray 2.30 homo-dimer 2 x NDP, 2 x UMP, 2 x U8Y HHblits 0.35
8jfb.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
V1/S quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with compound 4 (B21588), NADPH and dUMP
 0.68 28.39 0.97 2-158 X-ray 2.65 homo-dimer 2 x U86, 2 x NDP, 2 x UMP HHblits 0.35
3qg2.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex
 0.69 28.39 0.97 2-158 X-ray 2.30 homo-dimer 2 x CP6, 2 x NDP, 2 x UMP HHblits 0.35
3qg2.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex
 0.69 28.39 0.97 2-158 X-ray 2.30 homo-dimer 2 x CP6, 2 x NDP, 2 x UMP HHblits 0.35
6a2n.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum DHFR-TS complexed with BT2, NADPH, and dUMP
 0.68 28.39 0.97 2-158 X-ray 2.45 homo-dimer 2 x 9QR, 2 x NAP, 2 x UMP HHblits 0.35
6lhi.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with C466 (compound 42) and NADPH
 0.67 28.39 0.97 2-158 X-ray 2.59 homo-dimer 1 x MET, 2 x UMP, 2 x E9X, 2 x NDP HHblits 0.35
6a2p.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum DHFR-TS complexed with BT3, NADPH, and dUMP
 0.67 28.39 0.97 2-158 X-ray 2.60 homo-dimer 2 x 9RR, 1 x NAP, 2 x UMP HHblits 0.35
4eil.4.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal Structure of the loop truncated Toxoplasma gondii TS-DHFR
 0.58 33.11 0.95 3-153 X-ray 2.20 homo-dimer 2 x UMP, 2 x CB3, 2 x FOL, 2 x NDP BLAST 0.37
4eil.2.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal Structure of the loop truncated Toxoplasma gondii TS-DHFR
 0.58 33.11 0.95 3-153 X-ray 2.20 homo-dimer 2 x UMP, 2 x CB3, 2 x FOL, 2 x NDP BLAST 0.37
7f3z.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Double mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-K1, C59R+S108N) complexed with Trimethoprim (TOP), NADPH and dUMP
 0.67 28.39 0.97 2-158 X-ray 2.60 homo-dimer 2 x NDP, 2 x UMP, 2 x TOP HHblits 0.35
7f3z.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Double mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-K1, C59R+S108N) complexed with Trimethoprim (TOP), NADPH and dUMP
 0.67 28.39 0.97 2-158 X-ray 2.60 homo-dimer 2 x NDP, 2 x UMP, 2 x TOP HHblits 0.35
3um5.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Double mutant (A16V+S108T) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-T9/94) complexed with pyrimethamine, NADPH, and dUMP
 0.69 29.03 0.97 2-158 X-ray 2.40 homo-dimer 2 x CP6, 2 x NDP, 2 x UMP HHblits 0.35
3um5.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Double mutant (A16V+S108T) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-T9/94) complexed with pyrimethamine, NADPH, and dUMP
 0.69 29.03 0.97 2-158 X-ray 2.40 homo-dimer 2 x CP6, 2 x NDP, 2 x UMP HHblits 0.35
7k62.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate reductase from Mycobacterium kansasii in complex with NADP and inhibitor P218
 0.72 30.46 0.95 4-157 X-ray 2.05 monomer 1 x NAP, 1 x MMV HHblits 0.37
2bl9.1.A
DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE
X-ray crystal structure of Plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative
 0.67 32.47 0.97 3-158 X-ray 1.90 monomer 1 x NDP, 1 x CP6 HHblits 0.35
6vs5.1.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with 5-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid (fragment 1)
 0.72 0.00 26.62 0.97 1-158 X-ray 1.76 monomer 1 x CO, 2 x 9FH, 1 x NDP HHblits 0.35
6ddw.1.A
Dihydrofolate reductase
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}-2-hydroxybenzene-1-carbonyl)-L-glutamic acid
 0.73 0.00 26.62 0.97 1-158 X-ray 1.40 monomer 1 x NDP, 1 x G7D HHblits 0.35
6vv6.2.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with JEB113
 0.72 0.00 26.62 0.97 1-158 X-ray 2.24 monomer 1 x CO, 1 x NAP, 1 x RPJ HHblits 0.35
6vvb.1.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with 6-methyl-5-(4-phenylthiazol-2-yl)-2- (trifluoromethyl)nicotinic acid (fragment 10)
 0.72 0.00 26.62 0.97 1-158 X-ray 1.45 monomer 1 x RQ4, 1 x P33, 1 x NAP HHblits 0.35
8cop.1.B
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with N-(4-(2,6-diamino-5-(cyclopropylethynyl)pyrimidin-4-yl)phenyl)methanesulfonamide
 0.72 0.00 26.62 0.97 1-158 X-ray 1.80 homo-dimer 2 x NDP, 2 x VCI, 2 x CO HHblits 0.35
8cq9.1.B
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with 5-(cyclopropylethynyl)-6-(4-(trifluoromethyl)phenyl)pyrimidine-2,4-diamine
 0.72 0.00 26.62 0.97 1-158 X-ray 1.75 homo-dimer 2 x VFU, 2 x NDP, 2 x CO, 1 x MES HHblits 0.35
8cox.1.B
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with N-(2-(2,6-diamino-5-(cyclopropylethynyl)pyrimidin-4-yl)phenyl)methanesulfonamide
 0.71 0.00 26.62 0.97 1-158 X-ray 2.10 homo-dimer 2 x NDP, 2 x CO, 1 x VBJ HHblits 0.35
4dpd.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
WILD TYPE PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PfDHFR-TS), DHF COMPLEX, NADP+, dUMP
 0.67 28.39 0.97 2-158 X-ray 2.50 homo-dimer 1 x DHF, 1 x NAP, 2 x UMP HHblits 0.35
3qgt.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of Wild-type PfDHFR-TS COMPLEXED WITH NADPH, dUMP AND PYRIMETHAMINE
 0.68 28.39 0.97 2-158 X-ray 2.30 homo-dimer 2 x CP6, 2 x NDP, 2 x UMP HHblits 0.35
3qgt.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of Wild-type PfDHFR-TS COMPLEXED WITH NADPH, dUMP AND PYRIMETHAMINE
 0.67 28.39 0.97 2-158 X-ray 2.30 homo-dimer 2 x CP6, 2 x NDP, 2 x UMP HHblits 0.35
4dpd.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
WILD TYPE PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PfDHFR-TS), DHF COMPLEX, NADP+, dUMP
 0.68 28.39 0.97 2-158 X-ray 2.50 homo-dimer 1 x DHF, 1 x NAP, 2 x UMP HHblits 0.35
6a2o.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of wild type Plasmodium falciparum DHFR-TS complexed with BT3, NADPH, and dUMP
 0.68 28.39 0.97 2-158 X-ray 2.35 homo-dimer 2 x 9RR, 2 x NAP, 2 x UMP HHblits 0.35
6a2k.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of wild type Plasmodium falciparum DHFR-TS complexed with BT1, NADPH, and dUMP
 0.66 28.39 0.97 2-158 X-ray 2.38 homo-dimer 2 x 9QO, 2 x NAP, 2 x UMP HHblits 0.35
6a2o.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of wild type Plasmodium falciparum DHFR-TS complexed with BT3, NADPH, and dUMP
 0.66 28.39 0.97 2-158 X-ray 2.35 homo-dimer 2 x 9RR, 2 x NAP, 2 x UMP HHblits 0.35
6a2m.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of wild type Plasmodium falciparum DHFR-TS complexed with BT2, NADPH, and dUMP
 0.68 28.39 0.97 2-158 X-ray 2.20 homo-dimer 2 x 9QR, 2 x NAP, 2 x UMP HHblits 0.35
7f3y.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with methotrexate (MTX), NADPH and dUMP
 0.69 28.39 0.97 2-158 X-ray 2.25 homo-dimer 2 x NDP, 3 x MTX, 2 x UMP HHblits 0.35
7cty.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Wild type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS), fragment 263, NADP+, dUMP
 0.68 28.39 0.97 2-158 X-ray 2.80 homo-dimer 1 x NDP, 2 x GF3 HHblits 0.35
7f3y.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with methotrexate (MTX), NADPH and dUMP
 0.68 28.39 0.97 2-158 X-ray 2.25 homo-dimer 2 x NDP, 3 x MTX, 2 x UMP HHblits 0.35
7ctw.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with fragment 820, NADPH, dUMP
 0.63 28.39 0.97 2-158 X-ray 2.51 homo-dimer 2 x NDP, 1 x GEX HHblits 0.35
6cxm.1.A
Dihydrofolate reductase
Crystal structure of a dihydrofolate reductase from Mycobacterium smegmatis in complex with NADP and P218
 0.71 29.33 0.94 1-157 X-ray 2.65 monomer 1 x NAP, 1 x MMV HHblits 0.37
7l9t.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate reductase from Mycolicibacterium smegmatis in complex with SDDC-0001565 inhibitor
 0.68 29.33 0.94 1-157 X-ray 1.80 monomer 1 x QKJ HHblits 0.37
4m2x.2.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)
 0.72 0.00 26.80 0.96 2-158 X-ray 2.26 monomer 1 x NDP, 1 x TMQ HHblits 0.35
4m2x.1.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)
 0.71 26.80 0.96 2-158 X-ray 2.26 monomer 1 x NDP, 1 x TMQ HHblits 0.35
4m2x.4.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)
 0.72 26.80 0.96 2-158 X-ray 2.26 monomer 1 x NDP, 1 x TMQ HHblits 0.35
6nnh.3.B
Dihydrofolate reductase
Structure of Closed state of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and cycloguanil
 0.72 26.80 0.96 2-158 X-ray 1.52 homo-dimer 2 x 1CY, 2 x NDP, 2 x CO HHblits 0.35
6dds.1.A
Dihydrofolate reductase
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-5-methoxy-phenyl]benzoic acid
 0.72 26.80 0.96 2-158 X-ray 1.72 monomer 1 x NDP, 1 x U75 HHblits 0.35
6ddp.1.A
Dihydrofolate reductase
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and 3'-[(2R)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-5'-methoxy[1,1'-biphenyl]-4-carboxylic acid
 0.73 26.80 0.96 2-158 X-ray 1.49 monomer 1 x NDP, 1 x G6Y HHblits 0.35
6nnh.1.A
Dihydrofolate reductase
Structure of Closed state of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and cycloguanil
 0.72 26.80 0.96 2-158 X-ray 1.52 monomer 1 x 1CY, 1 x NDP, 1 x CO HHblits 0.35
6dds.2.A
Dihydrofolate reductase
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-5-methoxy-phenyl]benzoic acid
 0.73 26.80 0.96 2-158 X-ray 1.72 monomer 1 x NDP, 1 x U75 HHblits 0.35
1df7.1.A
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND METHOTREXATE
 0.73 26.80 0.96 2-158 X-ray 1.70 monomer 1 x NDP, 1 x MTX HHblits 0.35
5ja3.1.B
Dihydrofolate reductase
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta- NADPH and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-b iphenyl]-4-carboxylic acid (UCP1106)
 0.72 26.80 0.96 2-158 X-ray 1.81 homo-tetramer 4 x NDP, 4 x U06 HHblits 0.35
8cqa.1.B
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with N-(4-(2,6-diamino-5-(cyclopropylethynyl)pyrimidin-4-yl)phenyl)acetamide
 0.70 26.80 0.96 2-158 X-ray 2.00 homo-dimer 2 x VF6, 2 x NDP, 2 x CO, 1 x MES HHblits 0.35
8cqa.1.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with N-(4-(2,6-diamino-5-(cyclopropylethynyl)pyrimidin-4-yl)phenyl)acetamide
 0.71 26.80 0.96 2-158 X-ray 2.00 homo-dimer 2 x VF6, 2 x NDP, 2 x CO, 1 x MES HHblits 0.35
5u27.1.A
Dihydrofolate reductase
Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p65 Inhibitor
 0.72 26.80 0.96 2-158 X-ray 2.05 monomer 1 x NAP, 1 x P65 HHblits 0.35
4km0.2.A
Dihydrofolate reductase
Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with pyrimethamine
 0.70 26.80 0.96 2-158 X-ray 1.30 monomer 1 x CP6, 1 x ATR HHblits 0.35
4km2.1.A
Dihydrofolate reductase
Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in an open conformation in complex with trimethoprim
 0.71 26.80 0.96 2-158 X-ray 1.40 monomer 1 x ATR, 1 x TOP HHblits 0.35
4km2.2.A
Dihydrofolate reductase
Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in an open conformation in complex with trimethoprim
 0.70 26.80 0.96 2-158 X-ray 1.40 monomer 1 x ATR, 1 x TOP HHblits 0.35
4kl9.1.A
Dihydrofolate reductase
Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in the space group C2
 0.72 26.80 0.96 2-158 X-ray 1.39 monomer 1 x NDP, 1 x P33 HHblits 0.35
5sd2.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1236 (enantiomer)
 0.72 26.80 0.96 2-158 X-ray 2.00 monomer 1 x NAP, 1 x HJI HHblits 0.35
5scm.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-22
 0.73 26.80 0.96 2-158 X-ray 1.65 monomer 1 x GHU, 1 x NAP HHblits 0.35
5scp.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-23
 0.72 26.80 0.96 2-158 X-ray 1.80 monomer 1 x NAP, 1 x GWL HHblits 0.35
6vv7.2.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with JEB136
 0.72 26.80 0.96 2-158 X-ray 2.00 monomer 1 x NDP, 1 x CO, 1 x RPM HHblits 0.35
6vv8.1.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with JEB285
 0.72 26.80 0.96 2-158 X-ray 2.68 monomer 2 x CO, 1 x NAP, 1 x RPV HHblits 0.35
6vv9.2.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with JEB300
 0.72 26.80 0.96 2-158 X-ray 2.18 monomer 2 x CO, 1 x NDP, 1 x RQ1 HHblits 0.35
5ujf.1.A
Dihydrofolate reductase
Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound p218 Inhibitor
 0.70 26.80 0.96 2-158 X-ray 2.30 monomer 1 x MMV HHblits 0.35
2w3v.1.A
DIHYDROFOLATE REDUCTASE
MYCOBACTERIUM AVIUM DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM
 0.72 27.74 0.97 1-158 X-ray 1.89 monomer 1 x NDP, 1 x TOP HHblits 0.34
2cig.1.A
DIHYDROFOLATE REDUCTASE
Dihydrofolate reductase from Mycobacterium tuberculosis inhibited by the acyclic 4R isomer of INH-NADP a derivative of the prodrug isoniazid.
 0.72 26.14 0.96 2-158 X-ray 1.90 monomer 1 x 1DG HHblits 0.35
7rgj.1.B
Dihydrofolate reductase type 1
DfrA1 complexed with NADPH and 5-(3-(7-(4-(aminomethyl)phenyl)benzo[d][1,3]dioxol-5-yl)but-1-yn-1-yl)-6-ethylpyrimidine-2,4-diamine (UCP1223)
 0.72 30.26 0.96 1-158 X-ray 1.44 homo-dimer 2 x NAP, 2 x CA, 2 x 8MU, 1 x 560 HHblits 0.36
7myl.1.A
Dihydrofolate reductase
Crystal structure of DfrA1 dihydrofolate reductase in complex with TRIMETHOPRIM
 0.68 30.26 0.96 1-158 X-ray 2.15 homo-dimer 2 x TOP HHblits 0.35
6rul.1.A
GFP-LAMA-F98 a GFP enhancer nanobody with cpDHFR insertion,Dihydrofolate reductase,GFP-LAMA-F98 a GFP enhancer nanobody with cpDHFR insertion,Dihydrofolate reductase,Dihydrofolate reductase,GFP-LAMA-F98 a GFP enhancer nanobody with cpDHFR insertion,Dihydrofolate reductase,GFP-LAMA-F98 a GFP enhancer nanobody with cpDHFR insertion
Crystal structure of GFP-LAMA-F98 - a GFP enhancer nanobody with cpDHFR insertion and TMP and NADPH
 0.71 30.20 0.94 10-159 X-ray 2.20 monomer 1 x TOP, 1 x NDP HHblits 0.36
7r6g.1.A
Dihydrofolate reductase type 5
Crystal structure of DfrA5 dihydrofolate reductase in complex with TRIMETHOPRIM and NADPH
 0.72 29.61 0.96 1-158 X-ray 2.61 homo-dimer 2 x TOP, 2 x NDP HHblits 0.34
1vdr.1.A
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE
 0.69 25.17 0.95 1-158 X-ray 2.55 homo-dimer HHblits 0.35
1vdr.1.B
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE
 0.69 25.17 0.95 1-158 X-ray 2.55 homo-dimer HHblits 0.35
2ith.1.A
Dihydrofolate reductase
NMR Structure of Haloferax volcanii DHFR
 0.61 25.17 0.95 1-158 NMR 0.00 monomer HHblits 0.35
2jyb.1.A
Dihydrofolate reductase
binary hvDHFR1:folate complex
 0.60 25.17 0.95 1-158 NMR 0.00 monomer HHblits 0.35
1cz3.1.A
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA
 0.63 29.80 0.95 2-158 X-ray 2.10 homo-dimer HHblits 0.34
1d1g.1.B
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA
 0.62 29.80 0.95 2-158 X-ray 2.10 homo-dimer 2 x NDP, 2 x MTX HHblits 0.34
3l3r.1.A
Dihydrofolate reductase
Structural, Computational and Kinetic Data for Antifolate Interactions Against Pneumocystis jirovecii, Pneumocystis carinii and Human Dihydrofolate Reductase and Their Active Site Mutants
 0.61 0.00 30.77 0.90 2-144 X-ray 2.00 monomer 1 x OAG, 1 x NDP BLAST 0.37
3f8y.1.A
Dihydrofolate reductase
Correlations of Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes
 0.61 0.00 30.77 0.90 2-144 X-ray 1.45 monomer 1 x DH1, 1 x NDP BLAST 0.37
3ghv.1.A
Dihydrofolate reductase
Human dihydrofolate reductase Q35K/N64F double mutant inhibitor complex
 0.60 0.00 30.77 0.90 2-144 X-ray 1.30 monomer 1 x GHC, 1 x NDP BLAST 0.37
✓
 2w3m.1.A
DIHYDROFOLATE REDUCTASE
HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND FOLATE
 0.60 0.00 30.07 0.90 2-144 X-ray 1.60 monomer 1 x NDP, 1 x FOL BLAST 0.37
6dav.2.A
Dihydrofolate reductase
Crystal Structure of Human DHFR complexed with NADP and N10formyltetrahydrofolate
 0.61 0.00 30.07 0.90 2-144 X-ray 1.55 monomer 1 x NAP, 1 x G3V BLAST 0.37
3fs6.1.A
Dihydrofolate reductase
Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes
 0.61 30.07 0.90 2-144 X-ray 1.23 monomer 1 x DH1, 1 x NDP BLAST 0.37
3gyf.1.A
Dihydrofolate reductase
Human DHFR with Z-isomer in Orthorhombic lattice
 0.61 30.07 0.90 2-144 X-ray 1.70 monomer 1 x 51P, 1 x NDP BLAST 0.37
4m6l.1.A
Dihydrofolate reductase
Crystal structure of human dihydrofolate reductase (DHFR) bound to NADP+ and 5,10-dideazatetrahydrofolic acid
 0.61 30.07 0.90 2-144 X-ray 1.70 monomer 1 x 21V, 1 x NAP, 1 x DTT BLAST 0.37
4m6j.1.A
Dihydrofolate reductase
Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH
 0.61 30.07 0.90 2-144 X-ray 1.20 monomer 1 x NDP BLAST 0.37
7xi7.1.A
Dihydrofolate reductase
Human dihydrofolate reductase complexed with P39
 0.60 30.07 0.90 2-144 X-ray 1.65 monomer 1 x 4RI BLAST 0.37
1mvt.1.A
Dihydrofolate Reductase
Analysis of Two Polymorphic Forms of a Pyrido[2,3-d]pyrimidine N9-C10 Reverse-Bridge Antifolate Binary Complex with Human Dihydrofolate Reductase
 0.60 30.07 0.90 2-144 X-ray 1.80 monomer 1 x DTM BLAST 0.37
5sd7.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-735
 0.60 30.07 0.90 2-144 X-ray 1.80 monomer 1 x NAP, 1 x I0E BLAST 0.37
3nxo.1.A
Dihydrofolate reductase
Perferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for the E- and Z-isomers of a Series of 5-Substituted 2,4-Diaminofuro[2,3-d]pyrimidines as Ternary Complexes with NADPH and Human Dihydrofolate Reductase
 0.60 30.07 0.90 2-144 X-ray 1.35 monomer 1 x D2B, 1 x NDP BLAST 0.37
1pd8.1.A
Dihydrofolate reductase
Analysis of Three Crystal Structure Determinations of a 5-Methyl-6-N-Methylanilino Pyridopyrimidine Antifolate Complex with Human Dihydrofolate Reductase
 0.61 30.07 0.90 2-144 X-ray 2.10 monomer 1 x NDP, 1 x CO4 BLAST 0.37
1pd9.1.A
Dihydrofolate reductase
Analysis of Three Crystal Structure Determinations of a 5-Methyl-6-N-Methylanilino Pyridopyrimidine antifolate Complex with Human Dihydrofolate Reductase
 0.60 30.07 0.90 2-144 X-ray 2.20 monomer 1 x CO4 BLAST 0.37
1s3v.1.A
Dihydrofolate reductase
Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
 0.59 30.07 0.90 2-144 X-ray 1.80 monomer 1 x TQD BLAST 0.37
4keb.1.A
Dihydrofolate reductase
Human dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5-(isoquin-5-yl)phenyl]but-1-yn-1-yl}6-ethylpyrimidine-2,4-diamine
 0.61 30.07 0.90 2-144 X-ray 1.45 monomer 1 x NDP, 1 x 1QZ BLAST 0.37
4kd7.2.A
Dihydrofolate reductase
Human dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5(pyridine-4-yl)phenyl]prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4-diamine
 0.60 30.07 0.90 2-144 X-ray 2.72 monomer 1 x NDP, 1 x 9DR BLAST 0.37
1dhf.1.A
DIHYDROFOLATE REDUCTASE
CRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE
 0.61 30.07 0.90 2-144 X-ray 2.30 homo-dimer 2 x FOL BLAST 0.37
1dhf.1.B
DIHYDROFOLATE REDUCTASE
CRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE
 0.60 30.07 0.90 2-144 X-ray 2.30 homo-dimer 2 x FOL BLAST 0.37
5hsr.1.A
Dihydrofolate reductase
Fluorine substituted 5-methyl-6-(3',4'-difluoromethoxyphenythio)thieno[2,3-d]pyrimidine-2,4-diamine
 0.61 30.07 0.90 2-144 X-ray 1.21 monomer 1 x NDP, 2 x 63Y BLAST 0.37
1pdb.1.A
Dihydrofolate reductase
Analysis of Three Crystal Structure Determinations of a 5-Methyl-6-N-Methylanilino Pyridopyrimidine Antifolate Complex with Human Dihydrofolate Reductase
 0.60 30.07 0.90 2-144 X-ray 2.20 monomer BLAST 0.37
4g95.1.A
Dihydrofolate reductase
hDHFR-OAG binary complex
 0.60 30.07 0.90 2-144 X-ray 1.35 monomer 1 x OAG BLAST 0.37
3s7a.1.A
Dihydrofolate reductase
Human dihydrofolate reductase binary complex with PT684
 0.61 30.07 0.90 2-144 X-ray 1.80 monomer 1 x 684 BLAST 0.37
4keb.2.A
Dihydrofolate reductase
Human dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5-(isoquin-5-yl)phenyl]but-1-yn-1-yl}6-ethylpyrimidine-2,4-diamine
 0.60 30.07 0.90 2-144 X-ray 1.45 monomer 1 x NDP, 1 x FOL BLAST 0.37
1drf.1.A
DIHYDROFOLATE REDUCTASE
CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE
 0.60 30.07 0.90 2-144 X-ray 2.00 monomer 1 x FOL BLAST 0.37
1ohk.1.A
DIHYDROFOLATE REDUCTASE
HUMAN DIHYDROFOLATE REDUCTASE, ORTHORHOMBIC (P21 21 21) CRYSTAL FORM
 0.59 30.07 0.90 2-144 X-ray 2.50 monomer 1 x NDP, 1 x COP BLAST 0.37
1ohj.1.A
DIHYDROFOLATE REDUCTASE
HUMAN DIHYDROFOLATE REDUCTASE, MONOCLINIC (P21) CRYSTAL FORM
 0.60 30.07 0.90 2-144 X-ray 2.50 monomer 1 x NDP, 1 x COP BLAST 0.37
1kmv.1.A
DIHYDROFOLATE REDUCTASE
HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE (SRI-9662), A LIPOPHILIC ANTIFOLATE
 0.60 30.07 0.90 2-144 X-ray 1.05 monomer 1 x LII, 1 x NDP BLAST 0.37
1yho.1.A
Dihydrofolate reductase
Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures
 0.55 30.07 0.90 2-144 NMR 0.00 monomer 1 x NDP, 1 x TRR BLAST 0.37
6vcj.1.A
Dihydrofolate reductase
Crystal structure of hsDHFR in complex with NADP+, DAP, and R-naproxen
 0.61 30.07 0.90 2-144 X-ray 2.34 monomer 1 x LG3, 1 x NPX, 1 x NAP, 1 x FOL BLAST 0.37
7ese.1.A
Dihydrofolate reductase
The Crystal Structure of human DHFR from Biortus
 0.60 30.07 0.90 2-144 X-ray 1.85 monomer 1 x NAP, 1 x FOL BLAST 0.37
3f8z.1.A
Dihydrofolate reductase
Human Dihydrofolate Reductase Structural Data with Active Site Mutant Enzyme Complexes
 0.60 30.07 0.90 2-144 X-ray 2.01 monomer 1 x DH1, 1 x NDP BLAST 0.37
3ghc.1.A
Dihydrofolate reductase
Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-amino-4-oxo-5-substituted-6-thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agenst
 0.61 30.07 0.90 2-144 X-ray 1.30 monomer 1 x GHC, 1 x NDP BLAST 0.37
1hfq.1.A
DIHYDROFOLATE REDUCTASE
COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE
 0.60 30.07 0.90 2-144 X-ray 2.10 monomer 1 x NDP, 1 x MOT BLAST 0.37
3eig.1.A
Dihydrofolate reductase
Crystal structure of a methotrexate-resistant mutant of human dihydrofolate reductase
 0.59 30.07 0.90 2-144 X-ray 1.70 monomer 1 x MTX, 1 x CD BLAST 0.37
3f91.1.A
Dihydrofolate reductase
Structural Data for Human Active Site Mutant Enzyme Complexes
 0.60 30.07 0.90 2-144 X-ray 1.90 monomer 1 x DH1, 1 x NDP BLAST 0.37
3n0h.1.A
Dihydrofolate reductase
hDHFR double mutant Q35S/N64F Trimethoprim Binary Complex
 0.59 30.07 0.90 2-144 X-ray 1.92 monomer 2 x TOP BLAST 0.37
1hfp.1.A
DIHYDROFOLATE REDUCTASE
COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE
 0.60 30.07 0.90 2-144 X-ray 2.10 monomer 1 x NDP, 1 x MOT BLAST 0.37
1dlr.1.A
DIHYDROFOLATE REDUCTASE
METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE REDUCTASE WITH SUBSTITUTION OF LEUCINE 22: KINETICS, CRYSTALLOGRAPHY AND POTENTIAL AS SELECTABLE MARKERS
 0.61 29.37 0.90 2-144 X-ray 2.30 monomer 1 x NDP, 1 x MXA BLAST 0.37
3k45.1.A
Dihydrofolate reductase
Alternate Binding Modes Observed for the E- and Z-isomers of 2,4-Diaminofuro[2,3d]pyrimidines as Ternary Complexes with NADPH and Mouse Dihydrofolate Reductase
 0.59 32.39 0.89 3-144 X-ray 1.60 monomer 1 x NDP, 1 x 51P BLAST 0.37
1dls.1.A
DIHYDROFOLATE REDUCTASE
METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE REDUCTASE WITH SUBSTITUTION OF LEUCINE 22: KINETICS, CRYSTALLOGRAPHY AND POTENTIAL AS SELECTABLE MARKERS
 0.61 29.37 0.90 2-144 X-ray 2.30 monomer 1 x NDP, 1 x MTX BLAST 0.37
1u71.1.A
Dihydrofolate reductase
Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH
 0.60 29.37 0.90 2-144 X-ray 2.20 monomer 1 x MXA BLAST 0.36
3d84.1.A
Dihydrofolate reductase
Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with NADPH and a Ternary Complex with the Potent and Selective Inhibitor 2.4-Diamino-6-(-2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine
 0.61 31.69 0.89 3-144 X-ray 1.90 monomer 1 x NDP BLAST 0.37
1u70.1.A
Dihydrofolate reductase
Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase
 0.59 30.99 0.89 3-144 X-ray 2.50 monomer 1 x MTX, 1 x NDP BLAST 0.37
1dis.1.A
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEX WITH BRODIMOPRIM-4,6-DICARBOXYLATE
 0.65 38.81 0.84 4-137 NMR 0.00 monomer 1 x BDM BLAST 0.40
2l28.1.A
Dihydrofolate reductase
Solution structure of lactobacillus casei dihydrofolate reductase apo-form, 25 conformers
 0.56 38.81 0.84 4-137 NMR 0.00 monomer BLAST 0.40
2lf1.1.A
Dihydrofolate reductase
Solution structure of L. casei dihydrofolate reductase complexed with NADPH, 30 structures
 0.60 38.81 0.84 4-137 NMR 0.00 monomer 1 x NDP BLAST 0.40
2hm9.1.A
Dihydrofolate reductase
Solution structure of dihydrofolate reductase complexed with trimethoprim, 33 structures
 0.58 38.81 0.84 4-137 NMR 0.00 monomer 1 x TRR BLAST 0.40
1lud.1.A
DIHYDROFOLATE REDUCTASE
SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES
 0.62 38.81 0.84 4-137 NMR 0.00 monomer 1 x NDP, 1 x TRR BLAST 0.40
1bzf.1.A
DIHYDROFOLATE REDUCTASE
NMR SOLUTION STRUCTURE AND DYNAMICS OF THE COMPLEX OF LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE WITH THE NEW LIPOPHILIC ANTIFOLATE DRUG TRIMETREXATE, 22 STRUCTURES
 0.59 38.81 0.84 4-137 NMR 0.00 monomer 1 x TMQ BLAST 0.40
1ao8.1.A
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE, NMR, 21 STRUCTURES
 0.60 38.81 0.84 4-137 NMR 0.00 monomer 1 x MTX BLAST 0.40
2hqp.1.A
Dihydrofolate reductase
Solution structure of L.casei dihydrofolate reductase complexed with NADPH, 32 structures
 0.54 38.81 0.84 4-137 NMR 0.00 monomer 1 x NDP BLAST 0.40
3dfr.1.A
DIHYDROFOLATE REDUCTASE
CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE
 0.66 37.31 0.84 4-137 X-ray 1.70 monomer 1 x NDP, 1 x MTX BLAST 0.40
6rum.1.A
GFP-LAMA-G97 a GFP enhancer nanobody with cpDHFR insertion
Crystal structure of GFP-LAMA-G97 - a GFP enhancer nanobody with cpDHFR insertion and TMP and NADPH
 0.68 31.88 0.87 21-159 X-ray 1.60 monomer 1 x TOP, 1 x NDP HHblits 0.37
6cxm.1.A
Dihydrofolate reductase
Crystal structure of a dihydrofolate reductase from Mycobacterium smegmatis in complex with NADP and P218
 0.52 33.08 0.84 1-137 X-ray 2.65 monomer 1 x NAP, 1 x MMV BLAST 0.40
7l9t.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate reductase from Mycolicibacterium smegmatis in complex with SDDC-0001565 inhibitor
 0.50 33.08 0.84 1-137 X-ray 1.80 monomer 1 x QKJ BLAST 0.40
4ixf.1.A
Dihydrofolate reductase
pcDHFR-269 F69N variant
 0.54 35.82 0.84 2-136 X-ray 1.70 monomer 1 x NDP, 1 x IXF BLAST 0.39
3jtw.1.A
Dihydrofolate reductase
Crystal structure of Putative dihydrofolate reductase (YP_805003.1) from PEDIOCOCCUS PENTOSACEUS ATCC 25745 at 1.90 A resolution
 0.54 16.56 0.95 1-158 X-ray 1.90 homo-dimer HHblits 0.30
1vj3.1.A
DIHYDROFOLATE REDUCTASE
STRUCTURAL STUDIES ON BIO-ACTIVE COMPOUNDS. CRYSTAL STRUCTURE AND MOLECULAR MODELING STUDIES ON THE PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COFACTOR COMPLEX WITH TAB, A HIGHLY SELECTIVE ANTIFOLATE.
 0.53 35.82 0.84 2-136 X-ray 2.10 monomer 1 x NDP, 1 x TAB BLAST 0.39
2fzh.1.A
Dihydrofolate reductase
New Insights into Dihydrofolate Reductase Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives
 0.53 35.82 0.84 2-136 X-ray 2.10 monomer 1 x NDP, 1 x DH1 BLAST 0.39
1cd2.1.A
DIHYDROFOLATE REDUCTASE
LIGAND INDUCED CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURES OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEXES WITH FOLATE AND NADP+
 0.54 35.82 0.84 2-136 X-ray 2.20 monomer 1 x NAP, 1 x FOL BLAST 0.39
3cd2.1.A
DIHYDROFOLATE REDUCTASE
LIGAND INDUCED CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURES OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEXES WITH FOLATE AND NADP+
 0.53 35.82 0.84 2-136 X-ray 2.50 monomer 1 x NAP, 1 x MTX BLAST 0.39
4ixe.1.A
Dihydrofolate reductase
pcDHFR-NADPH-270
 0.54 35.82 0.84 2-136 X-ray 1.54 monomer 1 x IXE, 1 x NDP BLAST 0.39
4qjz.1.A
Dihydrofolate reductase
Pneumocystis carinii dihydrofolate reductase ternary complex with NADPH and the inhibitor 24, (N~6~-METHYL-N~6~-(NAPHTHALEN-1-YL)PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE)
 0.55 35.82 0.84 2-136 X-ray 1.61 monomer 1 x 33M, 1 x NDP BLAST 0.39
1e26.1.A
DIHYDROFOLATE REDUCTASE
Design, Synthesis and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent.
 0.54 35.82 0.84 2-136 X-ray 2.00 monomer 1 x NAP, 1 x GPB BLAST 0.39
4cd2.1.A
DIHYDROFOLATE REDUCTASE
LIGAND INDUCED CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURES OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEXES WITH FOLATE AND NADP+
 0.51 35.82 0.84 2-136 X-ray 2.00 monomer 1 x FOL BLAST 0.39
1s3y.1.A
Dihydrofolate reductase
Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
 0.53 35.82 0.84 2-136 X-ray 2.25 monomer 1 x NAP, 1 x TQT BLAST 0.39
1klk.1.A
Dihydrofolate reductase
CRYSTAL STRUCTURE OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE TERNARY COMPLEX WITH PT653 AND NADPH
 0.53 35.82 0.84 2-136 X-ray 2.30 monomer 1 x PMD, 1 x NDP BLAST 0.39
8jsy.1.A
Dihydrofolate reductase family protein
Dihydrofolate reductase-like enzyme from Leptospira interrogans
 0.56 17.11 0.96 1-158 X-ray 2.55 homo-dimer 2 x NAP HHblits 0.29
8jsy.3.A
Dihydrofolate reductase family protein
Dihydrofolate reductase-like enzyme from Leptospira interrogans
 0.56 17.11 0.96 1-158 X-ray 2.55 homo-dimer 2 x NAP HHblits 0.29
8jsy.3.B
Dihydrofolate reductase family protein
Dihydrofolate reductase-like enzyme from Leptospira interrogans
 0.56 17.11 0.96 1-158 X-ray 2.55 homo-dimer 2 x NAP HHblits 0.29
8jsy.2.B
Dihydrofolate reductase family protein
Dihydrofolate reductase-like enzyme from Leptospira interrogans
 0.56 17.11 0.96 1-158 X-ray 2.55 homo-dimer 2 x NAP HHblits 0.29
8jsy.1.B
Dihydrofolate reductase family protein
Dihydrofolate reductase-like enzyme from Leptospira interrogans
 0.55 17.11 0.96 1-158 X-ray 2.55 homo-dimer 2 x NAP HHblits 0.29
4ixg.1.A
Dihydrofolate reductase
pcDHFR-268-K37S-N69F variant
 0.54 35.07 0.84 2-136 X-ray 1.70 monomer 1 x NDP, 1 x IXG BLAST 0.39
3vco.1.A
Dihydrofolate reductase
Schistosoma mansoni Dihydrofolate reductase
 0.55 36.03 0.86 1-139 X-ray 1.95 monomer BLAST 0.37
3i3r.1.A
Dihydrofolate reductase/thymidylate synthase
X-ray structure dihydrofolate reductase/thymidylate synthase from babesia bovis at 2.35A resolution
 0.53 44.88 0.80 3-130 X-ray 2.35 homo-dimer BLAST 0.43
3nrr.1.A
Dihydrofolate reductase-thymidylate synthase
Co-crystal structure of dihydrofolate reductase-thymidylate synthase from Babesia bovis with dUMP, Raltitrexed and NADP
 0.55 44.88 0.80 3-130 X-ray 1.80 homo-dimer 2 x NAP, 4 x D16, 2 x UMP BLAST 0.43
4g8z.1.A
Dihydrofolate reductase
pcDHFR K37S/F69N double mutant TMP NADPH ternary complex
 0.55 34.33 0.84 2-136 X-ray 1.75 monomer 1 x TOP, 1 x NDP BLAST 0.38
3ky8.1.A
Putative riboflavin biosynthesis protein
Crystal structure of Putative riboflavin biosynthesis protein (YP_001092907.1) from SHEWANELLA SP. PV-4 at 2.12 A resolution
 0.53 22.52 0.95 1-158 X-ray 2.12 homo-dimer HHblits 0.29
3ky8.1.B
Putative riboflavin biosynthesis protein
Crystal structure of Putative riboflavin biosynthesis protein (YP_001092907.1) from SHEWANELLA SP. PV-4 at 2.12 A resolution
 0.53 22.52 0.95 1-158 X-ray 2.12 homo-dimer HHblits 0.29
6rul.1.A
GFP-LAMA-F98 a GFP enhancer nanobody with cpDHFR insertion,Dihydrofolate reductase,GFP-LAMA-F98 a GFP enhancer nanobody with cpDHFR insertion,Dihydrofolate reductase,Dihydrofolate reductase,GFP-LAMA-F98 a GFP enhancer nanobody with cpDHFR insertion,Dihydrofolate reductase,GFP-LAMA-F98 a GFP enhancer nanobody with cpDHFR insertion
Crystal structure of GFP-LAMA-F98 - a GFP enhancer nanobody with cpDHFR insertion and TMP and NADPH
 0.66 34.59 0.84 25-158 X-ray 2.20 monomer 1 x TOP, 1 x NDP BLAST 0.38
6rum.1.A
GFP-LAMA-G97 a GFP enhancer nanobody with cpDHFR insertion
Crystal structure of GFP-LAMA-G97 - a GFP enhancer nanobody with cpDHFR insertion and TMP and NADPH
 0.66 34.59 0.84 25-158 X-ray 1.60 monomer 1 x TOP, 1 x NDP BLAST 0.38
7xh2.1.A
Uncharacterized protein sfcH
Dihydrofolate Reductase-like Protein SacH in safracin biosynthesis
 0.55 18.42 0.96 1-158 X-ray 2.80 monomer 1 x NDP HHblits 0.27
2ith.1.A
Dihydrofolate reductase
NMR Structure of Haloferax volcanii DHFR
 0.51 29.85 0.84 1-134 NMR 0.00 monomer BLAST 0.37
2jyb.1.A
Dihydrofolate reductase
binary hvDHFR1:folate complex
 0.50 29.85 0.84 1-134 NMR 0.00 monomer BLAST 0.37
1vdr.1.A
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE
 0.60 29.85 0.84 1-134 X-ray 2.55 homo-dimer BLAST 0.37
1vdr.1.B
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE
 0.59 29.85 0.84 1-134 X-ray 2.55 homo-dimer BLAST 0.37
2gd9.1.A
Hypothetical protein yyaP
Crystal structure of a putative dihydrofolate reductase (bsu40760, yyap) from bacillus subtilis at 2.30 A resolution
 0.53 13.91 0.95 2-158 X-ray 2.30 homo-dimer HHblits 0.27
2xw7.1.A
DIHYDROFOLATE REDUCTASE
Structure of Mycobacterium smegmatis putative reductase MS0308
 0.54 16.89 0.93 2-158 X-ray 2.00 homo-dimer 2 x NDP HHblits 0.29
3hj3.1.A
Chain A, crystal structure of Dhfr
Crystal Structure of the ChTS-DHFR F207A Non-Active Site Mutant
 0.52 39.06 0.81 2-129 X-ray 2.70 homo-dimer 2 x UMP, 2 x CB3, 2 x MTX, 2 x NDP BLAST 0.40
1qzf.2.A
bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of DHFR-TS from Cryptosporidium hominis
 0.52 39.06 0.81 2-129 X-ray 2.80 homo-dimer 2 x UMP, 2 x CB3, 2 x FOL, 2 x NDP BLAST 0.40
6wep.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of TS-DHFR from Cryptosporidium hominis with Apo-TS site
 0.52 39.06 0.81 2-129 X-ray 2.79 homo-dimer 2 x NDP, 2 x MTX BLAST 0.40
3dl5.1.A
Dihydrofolate reductase, DHFR
Crystal Structure of the A287F Active Site Mutant of TS-DHFR from Cryptosporidium hominis
 0.51 39.06 0.81 2-129 X-ray 2.74 homo-dimer 2 x UMP, 2 x CB3, 2 x DHF, 2 x NDP BLAST 0.40
2oip.1.A
Chain A, crystal structure of Dhfr
Crystal Structure of the S290G Active Site Mutant of TS-DHFR from Cryptosporidium hominis
 0.52 39.06 0.81 2-129 X-ray 2.80 homo-dimer 2 x UMP, 2 x CB3, 2 x MTX, 2 x NDP BLAST 0.40
3dl6.1.A
Dihydrofolate reductase, DHFR
Crystal Structure of the A287F/S290G Active Site Mutant of TS-DHFR from Cryptosporidium hominis
 0.51 39.06 0.81 2-129 X-ray 3.25 homo-dimer 2 x UMP, 2 x CB3, 2 x DHF, 2 x NDP BLAST 0.40
2p4g.1.A
Hypothetical protein
CRYSTAL STRUCTURE OF A PYRIMIDINE REDUCTASE-LIKE PROTEIN (DIP1392) FROM CORYNEBACTERIUM DIPHTHERIAE NCTC AT 2.30 A RESOLUTION
 0.55 13.25 0.95 2-158 X-ray 2.30 homo-dimer HHblits 0.27
4ky4.3.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of non-classical TS inhibitor 2 in complex with Toxoplasma gondii TS-DHFR
 0.54 36.43 0.81 3-131 X-ray 2.79 homo-dimer 2 x UMP, 2 x 04J, 2 x NDP, 2 x 1UE BLAST 0.39
4eck.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal Structure of the Toxoplasma gondii TS-DHFR
 0.50 36.43 0.81 3-131 X-ray 3.52 homo-dimer 2 x UMP, 2 x CB3, 2 x FOL, 2 x NDP BLAST 0.39
4eck.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal Structure of the Toxoplasma gondii TS-DHFR
 0.50 36.43 0.81 3-131 X-ray 3.52 homo-dimer 2 x UMP, 2 x CB3, 2 x FOL, 2 x NDP BLAST 0.39
7fgx.2.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with P39, NADPH and dUMP
 0.54 36.43 0.81 3-131 X-ray 2.05 homo-dimer 2 x NDP, 2 x 4RI, 2 x UMP BLAST 0.39
7fgy.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with P40, NADPH and dUMP
 0.54 36.43 0.81 3-131 X-ray 2.67 homo-dimer 2 x NDP, 2 x 4TS, 2 x UMP BLAST 0.39
7fgy.2.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with P40, NADPH and dUMP
 0.53 36.43 0.81 3-131 X-ray 2.67 homo-dimer 2 x NDP, 2 x 4TS, 2 x UMP BLAST 0.39
7r6g.1.A
Dihydrofolate reductase type 5
Crystal structure of DfrA5 dihydrofolate reductase in complex with TRIMETHOPRIM and NADPH
 0.58 37.21 0.81 1-130 X-ray 2.61 homo-dimer 2 x TOP, 2 x NDP BLAST 0.38
5dxv.1.A
rethreaded DHFR
Crystal structure of Rethreaded DHFR
 0.55 29.01 0.82 1-134 X-ray 1.55 monomer 1 x NAP HHblits 0.36
5dxv.2.A
rethreaded DHFR
Crystal structure of Rethreaded DHFR
 0.57 29.01 0.82 1-134 X-ray 1.55 monomer HHblits 0.36
7rgj.1.B
Dihydrofolate reductase type 1
DfrA1 complexed with NADPH and 5-(3-(7-(4-(aminomethyl)phenyl)benzo[d][1,3]dioxol-5-yl)but-1-yn-1-yl)-6-ethylpyrimidine-2,4-diamine (UCP1223)
 0.58 37.10 0.78 1-125 X-ray 1.44 homo-dimer 2 x NAP, 2 x CA, 2 x 8MU, 1 x 560 BLAST 0.39
7myl.1.A
Dihydrofolate reductase
Crystal structure of DfrA1 dihydrofolate reductase in complex with TRIMETHOPRIM
 0.55 37.10 0.78 1-125 X-ray 2.15 homo-dimer 2 x TOP BLAST 0.39
7k6c.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium abscessus ATCC 19977 / DSM 44196 with NADP and inhibitor P218
 0.63 33.06 0.78 2-125 X-ray 2.00 monomer 1 x NAP, 1 x MMV, 1 x CA BLAST 0.38
1juv.1.A
DIHYDROFOLATE REDUCTASE
Crystal structure analysis of Dihydrofolate reductase from Bacteriophage T4
 0.49 21.64 0.84 2-136 X-ray 1.70 homo-dimer 2 x NDP HHblits 0.32
7zzx.1.A
Dihydrofolate reductase
Crystal structure of Candida auris DHFR in apo form
 0.38 37.82 0.75 15-135 X-ray 2.40 monomer BLAST 0.41
8a0z.1.A
Dihydrofolate reductase
Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and pyrimethamine
 0.40 37.82 0.75 15-135 X-ray 1.70 monomer 1 x NDP, 1 x CP6 BLAST 0.41
8a0z.2.A
Dihydrofolate reductase
Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and pyrimethamine
 0.40 37.82 0.75 15-135 X-ray 1.70 monomer 1 x NDP, 1 x CP6 BLAST 0.41
8crh.1.A
Dihydrofolate reductase
Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and cycloguanil
 0.40 37.82 0.75 15-135 X-ray 1.30 homo-dimer 4 x VIL, 2 x NDP BLAST 0.41
8crh.1.B
Dihydrofolate reductase
Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and cycloguanil
 0.40 37.82 0.75 15-135 X-ray 1.30 homo-dimer 4 x VIL, 2 x NDP BLAST 0.41
8a0n.1.A
Dihydrofolate reductase
Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH
 0.38 37.82 0.75 15-135 X-ray 1.40 monomer 1 x NDP BLAST 0.41
8e4f.1.A
Dihydrofolate reductase
Crystal structure of dihydrofolate reductase (DHFR) from the filarial nematode W. bancrofti in complex with NADPH and folate
 0.58 37.40 0.77 3-125 X-ray 2.47 monomer 1 x NAP, 1 x FOL BLAST 0.38
6uww.1.A
Dihydrofolate reductase
Crystal structure of dihydrofolate reductase from Mycobacterium ulcerans with P218 inhibitor
 0.58 35.29 0.75 2-126 X-ray 0.92 monomer 1 x MMV, 1 x NAP BLAST 0.39
7km7.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001914, tetragonal crystal from
 0.58 35.29 0.75 2-126 X-ray 1.80 monomer 1 x NAP, 1 x WPD, 1 x BR BLAST 0.39
1ia2.2.A
DIHYDROFOLATE REDUCTASE
Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) and 5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE (GW578)
 0.45 38.46 0.74 15-132 X-ray 1.82 monomer 1 x NDP, 1 x TQ4, 1 x MES BLAST 0.41
1ia2.1.A
DIHYDROFOLATE REDUCTASE
Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) and 5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE (GW578)
 0.43 38.46 0.74 15-132 X-ray 1.82 monomer 1 x NDP, 1 x TQ4, 1 x MES BLAST 0.41
3qlw.1.A
Putative uncharacterized protein CaJ7.0360
Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine (UCP120B)
 0.43 38.46 0.74 15-132 X-ray 2.50 monomer 1 x NDP, 1 x N22 BLAST 0.41
3qls.1.A
Putative uncharacterized protein CaJ7.0360
Candida albicans dihydrofolate reductase complexed with NADPH and 6-methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP115A)
 0.45 38.46 0.74 15-132 X-ray 1.73 monomer 1 x NDP, 1 x 55V, 1 x GLY BLAST 0.41
4h95.1.A
Dihydrofolate Reductase
Candida albicans dihydrofolate reductase complexed with NADPH and 6-ethyl-5-{3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine (UCP1006)
 0.44 38.46 0.74 15-132 X-ray 2.60 monomer 1 x NDP, 1 x 06U BLAST 0.41
4h97.1.A
Dihydrofolate Reductase
Candida albicans dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5-(4-methylphenyl)phenyl]but-1-yn-1-yl}-6-methylpyrimidine-2,4-diamine (UCP111D4M)
 0.44 38.46 0.74 15-132 X-ray 2.20 monomer 1 x NDP, 1 x 53S BLAST 0.41
3kgy.1.A
Bifunctional deaminase-reductase domain protein
Crystal structure of Putative dihydrofolate reductase (YP_001636057.1) from CHLOROFLEXUS AURANTIACUS J-10-FL at 1.50 A resolution
 0.45 16.79 0.86 1-137 X-ray 1.50 homo-dimer 2 x NDP HHblits 0.28
4ha7.1.A
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase
Structural insights into the reduction mechanism of Saccharomyces cerevisia Riboflavin Biosynthesis Reductase Rib7
 0.45 13.24 0.86 2-137 X-ray 2.10 homo-dimer HHblits 0.28
4ha7.1.B
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase
Structural insights into the reduction mechanism of Saccharomyces cerevisia Riboflavin Biosynthesis Reductase Rib7
 0.41 13.24 0.86 2-137 X-ray 2.10 homo-dimer HHblits 0.28
5dxv.1.A
rethreaded DHFR
Crystal structure of Rethreaded DHFR
 0.48 34.48 0.73 1-117 X-ray 1.55 monomer 1 x NAP BLAST 0.39
5dxv.2.A
rethreaded DHFR
Crystal structure of Rethreaded DHFR
 0.50 34.48 0.73 1-117 X-ray 1.55 monomer BLAST 0.39
7lrh.1.A
Riboflavin biosynthesis protein RibD
C-terminal domain of RibD from Brucella abortus (5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate reductase)
 0.40 14.07 0.85 3-137 X-ray 1.92 homo-dimer HHblits 0.27
7lrh.1.B
Riboflavin biosynthesis protein RibD
C-terminal domain of RibD from Brucella abortus (5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate reductase)
 0.41 14.07 0.85 3-137 X-ray 1.92 homo-dimer HHblits 0.27
7lrh.2.A
Riboflavin biosynthesis protein RibD
C-terminal domain of RibD from Brucella abortus (5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate reductase)
 0.41 14.07 0.85 3-137 X-ray 1.92 homo-dimer HHblits 0.27
7lrh.2.B
Riboflavin biosynthesis protein RibD
C-terminal domain of RibD from Brucella abortus (5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate reductase)
 0.40 14.07 0.85 3-137 X-ray 1.92 homo-dimer HHblits 0.27
7k68.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001565
 0.55 34.21 0.72 2-115 X-ray 1.45 monomer 1 x NAP, 1 x QKJ BLAST 0.39
8ta1.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM907
 0.57 34.21 0.72 2-115 X-ray 1.50 monomer BLAST 0.39
7km9.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001913, tetragonal crystal from
 0.57 34.21 0.72 2-115 X-ray 1.95 monomer 1 x NAP, 1 x WPJ, 1 x BR BLAST 0.39
6uwq.1.A
Dihydrofolate reductase
Crystal structure of dihydrofolate reductase from Mycobacterium ulcerans with SDDC-0001565 inhibitor
 0.54 34.21 0.72 2-115 X-ray 1.50 monomer 1 x NAP, 1 x QKJ BLAST 0.39
2w3v.1.A
DIHYDROFOLATE REDUCTASE
MYCOBACTERIUM AVIUM DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM
 0.54 34.51 0.71 3-115 X-ray 1.89 monomer 1 x NDP, 1 x TOP BLAST 0.38
7k62.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate reductase from Mycobacterium kansasii in complex with NADP and inhibitor P218
 0.53 36.70 0.69 4-112 X-ray 2.05 monomer 1 x NAP, 1 x MMV BLAST 0.40
3um5.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Double mutant (A16V+S108T) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-T9/94) complexed with pyrimethamine, NADPH, and dUMP
 0.36 40.19 0.67 27-136 X-ray 2.40 homo-dimer 2 x CP6, 2 x NDP, 2 x UMP BLAST 0.41
3um5.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Double mutant (A16V+S108T) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-T9/94) complexed with pyrimethamine, NADPH, and dUMP
 0.36 40.19 0.67 27-136 X-ray 2.40 homo-dimer 2 x CP6, 2 x NDP, 2 x UMP BLAST 0.41
4dpd.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
WILD TYPE PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PfDHFR-TS), DHF COMPLEX, NADP+, dUMP
 0.38 39.25 0.67 27-136 X-ray 2.50 homo-dimer 1 x DHF, 1 x NAP, 2 x UMP BLAST 0.41
3qgt.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of Wild-type PfDHFR-TS COMPLEXED WITH NADPH, dUMP AND PYRIMETHAMINE
 0.37 39.25 0.67 27-136 X-ray 2.30 homo-dimer 2 x CP6, 2 x NDP, 2 x UMP BLAST 0.41
3qgt.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of Wild-type PfDHFR-TS COMPLEXED WITH NADPH, dUMP AND PYRIMETHAMINE
 0.38 39.25 0.67 27-136 X-ray 2.30 homo-dimer 2 x CP6, 2 x NDP, 2 x UMP BLAST 0.41
4dpd.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
WILD TYPE PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PfDHFR-TS), DHF COMPLEX, NADP+, dUMP
 0.37 39.25 0.67 27-136 X-ray 2.50 homo-dimer 1 x DHF, 1 x NAP, 2 x UMP BLAST 0.41
6a2o.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of wild type Plasmodium falciparum DHFR-TS complexed with BT3, NADPH, and dUMP
 0.36 39.25 0.67 27-136 X-ray 2.35 homo-dimer 2 x 9RR, 2 x NAP, 2 x UMP BLAST 0.41
6a2k.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of wild type Plasmodium falciparum DHFR-TS complexed with BT1, NADPH, and dUMP
 0.35 39.25 0.67 27-136 X-ray 2.38 homo-dimer 2 x 9QO, 2 x NAP, 2 x UMP BLAST 0.41
6a2o.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of wild type Plasmodium falciparum DHFR-TS complexed with BT3, NADPH, and dUMP
 0.35 39.25 0.67 27-136 X-ray 2.35 homo-dimer 2 x 9RR, 2 x NAP, 2 x UMP BLAST 0.41
6a2m.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of wild type Plasmodium falciparum DHFR-TS complexed with BT2, NADPH, and dUMP
 0.36 39.25 0.67 27-136 X-ray 2.20 homo-dimer 2 x 9QR, 2 x NAP, 2 x UMP BLAST 0.41
7f3y.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with methotrexate (MTX), NADPH and dUMP
 0.37 39.25 0.67 27-136 X-ray 2.25 homo-dimer 2 x NDP, 3 x MTX, 2 x UMP BLAST 0.41
7cty.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Wild type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS), fragment 263, NADP+, dUMP
 0.39 39.25 0.67 27-136 X-ray 2.80 homo-dimer 1 x NDP, 2 x GF3 BLAST 0.41
7f3y.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with methotrexate (MTX), NADPH and dUMP
 0.36 39.25 0.67 27-136 X-ray 2.25 homo-dimer 2 x NDP, 3 x MTX, 2 x UMP BLAST 0.41
7ctw.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with fragment 820, NADPH, dUMP
 0.36 39.25 0.67 27-136 X-ray 2.51 homo-dimer 2 x NDP, 1 x GEX BLAST 0.41
8wgm.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS V1/S, N51I+C59R+S108N+I164L) complexed with LA1, NADPH and dUMP
 0.36 39.25 0.67 27-136 X-ray 2.15 homo-dimer BLAST 0.41
8wgm.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS V1/S, N51I+C59R+S108N+I164L) complexed with LA1, NADPH and dUMP
 0.36 39.25 0.67 27-136 X-ray 2.15 homo-dimer BLAST 0.41
8jfb.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
V1/S quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with compound 4 (B21588), NADPH and dUMP
 0.36 39.25 0.67 27-136 X-ray 2.65 homo-dimer 2 x U86, 2 x NDP, 2 x UMP BLAST 0.41
8jfd.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
V1/S quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with compound 8 (B21594), NADPH and dUMP
 0.35 39.25 0.67 27-136 X-ray 2.30 homo-dimer 2 x NDP, 2 x UMP, 2 x U8Y BLAST 0.41
8jfb.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
V1/S quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with compound 4 (B21588), NADPH and dUMP
 0.35 39.25 0.67 27-136 X-ray 2.65 homo-dimer 2 x U86, 2 x NDP, 2 x UMP BLAST 0.41
3qg2.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex
 0.36 39.25 0.67 27-136 X-ray 2.30 homo-dimer 2 x CP6, 2 x NDP, 2 x UMP BLAST 0.41
3qg2.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex
 0.37 39.25 0.67 27-136 X-ray 2.30 homo-dimer 2 x CP6, 2 x NDP, 2 x UMP BLAST 0.41
6a2n.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum DHFR-TS complexed with BT2, NADPH, and dUMP
 0.35 39.25 0.67 27-136 X-ray 2.45 homo-dimer 2 x 9QR, 2 x NAP, 2 x UMP BLAST 0.41
6lhi.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with C466 (compound 42) and NADPH
 0.38 39.25 0.67 27-136 X-ray 2.59 homo-dimer 1 x MET, 2 x UMP, 2 x E9X, 2 x NDP BLAST 0.41
6a2p.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum DHFR-TS complexed with BT3, NADPH, and dUMP
 0.36 39.25 0.67 27-136 X-ray 2.60 homo-dimer 2 x 9RR, 1 x NAP, 2 x UMP BLAST 0.41
7f3z.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Double mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-K1, C59R+S108N) complexed with Trimethoprim (TOP), NADPH and dUMP
 0.36 39.25 0.67 27-136 X-ray 2.60 homo-dimer 2 x NDP, 2 x UMP, 2 x TOP BLAST 0.41
7f3z.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Double mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS-K1, C59R+S108N) complexed with Trimethoprim (TOP), NADPH and dUMP
 0.37 39.25 0.67 27-136 X-ray 2.60 homo-dimer 2 x NDP, 2 x UMP, 2 x TOP BLAST 0.41
2hxv.1.A
Diaminohydroxyphosphoribosylaminopyrimidine deaminase/ 5-amino-6-(5-phosphoribosylamino)uracil reductase
Crystal structure of a diaminohydroxyphosphoribosylaminopyrimidine deaminase/ 5-amino-6-(5-phosphoribosylamino)uracil reductase (tm1828) from thermotoga maritima at 1.80 A resolution
 0.44 20.00 0.79 1-125 X-ray 1.80 homo-dimer 2 x ZN, 2 x NDP HHblits 0.29
3dga.2.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF01302, NADPH, and dUMP
 0.37 39.25 0.67 27-136 X-ray 2.70 hetero-1-1-mer 1 x RJ1, 1 x NDP, 1 x UMP BLAST 0.41
3dga.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF01302, NADPH, and dUMP
 0.38 39.25 0.67 27-136 X-ray 2.70 hetero-1-1-mer 1 x RJ1, 1 x NDP, 1 x UMP BLAST 0.41
1j3i.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with WR99210, NADPH, and dUMP
 0.37 39.25 0.67 27-136 X-ray 2.33 hetero-2-2-mer 2 x WRA, 2 x NDP, 2 x UMP BLAST 0.41
1j3i.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with WR99210, NADPH, and dUMP
 0.42 39.25 0.67 27-136 X-ray 2.33 hetero-2-2-mer 2 x WRA, 2 x NDP, 2 x UMP BLAST 0.41
3dg8.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF670, NADPH, and dUMP
 0.36 39.25 0.67 27-136 X-ray 2.58 hetero-1-1-mer 1 x RJ6, 1 x NDP, 1 x UMP BLAST 0.41
3dg8.2.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF670, NADPH, and dUMP
 0.37 39.25 0.67 27-136 X-ray 2.58 hetero-1-1-mer 1 x RJ6, 1 x NDP, 1 x UMP BLAST 0.41
1j3k.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with WR99210, NADPH, and dUMP
 0.37 39.25 0.67 27-136 X-ray 2.10 hetero-2-2-mer 2 x WRA, 2 x NDP, 2 x UMP BLAST 0.41
1j3k.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with WR99210, NADPH, and dUMP
 0.36 39.25 0.67 27-136 X-ray 2.10 hetero-2-2-mer 2 x WRA, 2 x NDP, 2 x UMP BLAST 0.41
1j3j.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Double mutant (C59R+S108N) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with pyrimethamine, NADPH, and dUMP
 0.37 39.25 0.67 27-136 X-ray 2.30 hetero-2-2-mer 2 x CP6, 2 x NDP, 2 x UMP BLAST 0.41
1j3j.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Double mutant (C59R+S108N) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with pyrimethamine, NADPH, and dUMP
 0.37 39.25 0.67 27-136 X-ray 2.30 hetero-2-2-mer 2 x CP6, 2 x NDP, 2 x UMP BLAST 0.41
6p8c.1.A
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase
2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase (MthRED) from Methanothermobacter thermautotrophicus
 0.43 18.40 0.79 2-126 X-ray 2.07 homo-dimer 1 x MG, 2 x NAP HHblits 0.28
2o7p.1.A
Riboflavin biosynthesis protein ribD
The crystal structure of RibD from Escherichia coli in complex with the oxidised NADP+ cofactor in the active site of the reductase domain
 0.41 12.00 0.79 2-126 X-ray 3.00 homo-dimer 2 x NAP HHblits 0.28
2o7p.1.B
Riboflavin biosynthesis protein ribD
The crystal structure of RibD from Escherichia coli in complex with the oxidised NADP+ cofactor in the active site of the reductase domain
 0.40 12.00 0.79 2-126 X-ray 3.00 homo-dimer 2 x NAP HHblits 0.28
3zpg.1.A
RIBD
Acinetobacter baumannii RibD, form 2
 0.40 18.03 0.77 2-123 X-ray 1.99 homo-dimer 2 x ZN, 4 x 5GP, 4 x OXL, 2 x CAC HHblits 0.28
3zpc.1.B
RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD
Acinetobacter baumannii RibD, form 1
 0.37 18.03 0.77 2-123 X-ray 2.20 homo-dimer 2 x ZN HHblits 0.28
3zpc.1.A
RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD
Acinetobacter baumannii RibD, form 1
 0.38 18.03 0.77 2-123 X-ray 2.20 homo-dimer 2 x ZN HHblits 0.28
2azn.1.A
Putative 5-amino-6-(5-phosphoribosylamino)uracil reductase
X-RAY Structure of 2,5-diamino-6-ribosylamino-4(3h)-pyrimidinone 5-phosphate reductase
 0.42 19.49 0.74 2-119 X-ray 2.70 monomer 1 x MA5, 1 x NAP HHblits 0.29
2g6v.1.A
Riboflavin biosynthesis protein ribD
The crystal structure of ribD from Escherichia coli
 0.41 12.71 0.74 2-119 X-ray 2.60 homo-dimer HHblits 0.28
2g6v.1.B
Riboflavin biosynthesis protein ribD
The crystal structure of ribD from Escherichia coli
 0.39 12.71 0.74 2-119 X-ray 2.60 homo-dimer HHblits 0.28
5xv5.1.A
Conserved protein
Crystal structure of Rib7 mutant S88E from Methanosarcina mazei
 0.42 16.95 0.74 2-119 X-ray 2.50 homo-dimer HHblits 0.28
5xv5.1.B
Conserved protein
Crystal structure of Rib7 mutant S88E from Methanosarcina mazei
 0.42 16.95 0.74 2-119 X-ray 2.50 homo-dimer HHblits 0.28
2bl9.1.A
DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE
X-ray crystal structure of Plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative
 0.34 41.58 0.64 39-139 X-ray 1.90 monomer 1 x NDP, 1 x CP6 BLAST 0.40
2bla.1.A
DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE
SP21 double mutant P. vivax Dihydrofolate reductase in complex with pyrimethamine
 0.36 41.58 0.64 39-139 X-ray 2.50 monomer 1 x NDP, 1 x CP6, 1 x MES BLAST 0.40
2blc.1.A
DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE
SP21 double mutant P. vivax Dihydrofolate reductase in complex with des-chloropyrimethamine
 0.37 41.58 0.64 39-139 X-ray 2.25 monomer 1 x NDP, 1 x CP7, 1 x MES BLAST 0.40
5xux.1.A
Conserved protein
Crystal structure of Rib7 from Methanosarcina mazei
 0.43 17.95 0.74 3-119 X-ray 2.27 homo-dimer 2 x NAP HHblits 0.28
5xv0.1.B
Conserved protein
Crystal structure of Rib7 mutant D33N from Methanosarcina mazei
 0.41 16.24 0.74 3-119 X-ray 1.95 homo-dimer 2 x NAP HHblits 0.28
5xv0.1.A
Conserved protein
Crystal structure of Rib7 mutant D33N from Methanosarcina mazei
 0.41 16.24 0.74 3-119 X-ray 1.95 homo-dimer 2 x NAP HHblits 0.28
5xv0.2.A
Conserved protein
Crystal structure of Rib7 mutant D33N from Methanosarcina mazei
 0.40 16.24 0.74 3-119 X-ray 1.95 homo-dimer 2 x NAP HHblits 0.28
5xv2.1.A
Conserved protein
Crystal structure of Rib7 mutant D33A from Methanosarcina mazei
 0.42 16.10 0.74 2-119 X-ray 2.00 homo-dimer 2 x NAP HHblits 0.27
3ro9.1.A
Strain CBS138 chromosome J complete sequence
Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)
 0.31 36.00 0.63 15-114 X-ray 2.60 monomer 1 x NDP, 1 x 06U BLAST 0.39
3qlx.2.A
Dihydrofolate reductase
Candida glabrata dihydrofolate reductase complexed with NADPH and 6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)pent-1-yn-1-yl]pyrimidine-2,4-diamine (UCP112A)
 0.30 36.00 0.63 15-114 X-ray 2.24 monomer 1 x NDP, 1 x QLR BLAST 0.39
4h98.1.A
Dihydrofolate Reductase
Candida glabrata dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)
 0.30 36.00 0.63 15-114 X-ray 2.90 monomer 1 x NDP, 1 x 14Q BLAST 0.39
5ujf.1.A
Dihydrofolate reductase
Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound p218 Inhibitor
 0.34 40.00 0.60 2-96 X-ray 2.30 monomer 1 x MMV BLAST 0.41
6nnh.3.B
Dihydrofolate reductase
Structure of Closed state of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and cycloguanil
 0.35 40.43 0.59 3-96 X-ray 1.52 homo-dimer 2 x 1CY, 2 x NDP, 2 x CO BLAST 0.41
6dds.1.A
Dihydrofolate reductase
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-5-methoxy-phenyl]benzoic acid
 0.35 40.43 0.59 3-96 X-ray 1.72 monomer 1 x NDP, 1 x U75 BLAST 0.41
6ddp.1.A
Dihydrofolate reductase
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and 3'-[(2R)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-5'-methoxy[1,1'-biphenyl]-4-carboxylic acid
 0.35 40.43 0.59 3-96 X-ray 1.49 monomer 1 x NDP, 1 x G6Y BLAST 0.41
6nnh.1.A
Dihydrofolate reductase
Structure of Closed state of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and cycloguanil
 0.35 40.43 0.59 3-96 X-ray 1.52 monomer 1 x 1CY, 1 x NDP, 1 x CO BLAST 0.41
6dds.2.A
Dihydrofolate reductase
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-5-methoxy-phenyl]benzoic acid
 0.35 40.43 0.59 3-96 X-ray 1.72 monomer 1 x NDP, 1 x U75 BLAST 0.41
1df7.1.A
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND METHOTREXATE
 0.35 40.43 0.59 3-96 X-ray 1.70 monomer 1 x NDP, 1 x MTX BLAST 0.41
5ja3.1.B
Dihydrofolate reductase
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta- NADPH and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-b iphenyl]-4-carboxylic acid (UCP1106)
 0.35 40.43 0.59 3-96 X-ray 1.81 homo-tetramer 4 x NDP, 4 x U06 BLAST 0.41
8cqa.1.B
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with N-(4-(2,6-diamino-5-(cyclopropylethynyl)pyrimidin-4-yl)phenyl)acetamide
 0.33 40.43 0.59 3-96 X-ray 2.00 homo-dimer 2 x VF6, 2 x NDP, 2 x CO, 1 x MES BLAST 0.41
8cqa.1.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with N-(4-(2,6-diamino-5-(cyclopropylethynyl)pyrimidin-4-yl)phenyl)acetamide
 0.35 40.43 0.59 3-96 X-ray 2.00 homo-dimer 2 x VF6, 2 x NDP, 2 x CO, 1 x MES BLAST 0.41
6vs5.1.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with 5-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid (fragment 1)
 0.35 40.43 0.59 3-96 X-ray 1.76 monomer 1 x CO, 2 x 9FH, 1 x NDP BLAST 0.41
6ddw.1.A
Dihydrofolate reductase
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}-2-hydroxybenzene-1-carbonyl)-L-glutamic acid
 0.35 40.43 0.59 3-96 X-ray 1.40 monomer 1 x NDP, 1 x G7D BLAST 0.41
6vv6.2.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with JEB113
 0.35 40.43 0.59 3-96 X-ray 2.24 monomer 1 x CO, 1 x NAP, 1 x RPJ BLAST 0.41
6vv7.2.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with JEB136
 0.35 40.43 0.59 3-96 X-ray 2.00 monomer 1 x NDP, 1 x CO, 1 x RPM BLAST 0.41
6vv8.1.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with JEB285
 0.35 40.43 0.59 3-96 X-ray 2.68 monomer 2 x CO, 1 x NAP, 1 x RPV BLAST 0.41
6vv9.2.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with JEB300
 0.34 40.43 0.59 3-96 X-ray 2.18 monomer 2 x CO, 1 x NDP, 1 x RQ1 BLAST 0.41
6vvb.1.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with 6-methyl-5-(4-phenylthiazol-2-yl)-2- (trifluoromethyl)nicotinic acid (fragment 10)
 0.34 40.43 0.59 3-96 X-ray 1.45 monomer 1 x RQ4, 1 x P33, 1 x NAP BLAST 0.41
8cop.1.B
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with N-(4-(2,6-diamino-5-(cyclopropylethynyl)pyrimidin-4-yl)phenyl)methanesulfonamide
 0.33 40.43 0.59 3-96 X-ray 1.80 homo-dimer 2 x NDP, 2 x VCI, 2 x CO BLAST 0.41
8cq9.1.B
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with 5-(cyclopropylethynyl)-6-(4-(trifluoromethyl)phenyl)pyrimidine-2,4-diamine
 0.34 40.43 0.59 3-96 X-ray 1.75 homo-dimer 2 x VFU, 2 x NDP, 2 x CO, 1 x MES BLAST 0.41
8cox.1.B
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase in complex with N-(2-(2,6-diamino-5-(cyclopropylethynyl)pyrimidin-4-yl)phenyl)methanesulfonamide
 0.35 40.43 0.59 3-96 X-ray 2.10 homo-dimer 2 x NDP, 2 x CO, 1 x VBJ BLAST 0.41
4m2x.2.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)
 0.35 40.43 0.59 3-96 X-ray 2.26 monomer 1 x NDP, 1 x TMQ BLAST 0.41
4m2x.1.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)
 0.36 40.43 0.59 3-96 X-ray 2.26 monomer 1 x NDP, 1 x TMQ BLAST 0.41
4m2x.4.A
Dihydrofolate reductase
Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)
 0.37 40.43 0.59 3-96 X-ray 2.26 monomer 1 x NDP, 1 x TMQ BLAST 0.41
5u27.1.A
Dihydrofolate reductase
Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p65 Inhibitor
 0.36 40.43 0.59 3-96 X-ray 2.05 monomer 1 x NAP, 1 x P65 BLAST 0.41
4km0.2.A
Dihydrofolate reductase
Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with pyrimethamine
 0.33 40.43 0.59 3-96 X-ray 1.30 monomer 1 x CP6, 1 x ATR BLAST 0.41
4km2.1.A
Dihydrofolate reductase
Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in an open conformation in complex with trimethoprim
 0.33 40.43 0.59 3-96 X-ray 1.40 monomer 1 x ATR, 1 x TOP BLAST 0.41
4km2.2.A
Dihydrofolate reductase
Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in an open conformation in complex with trimethoprim
 0.34 40.43 0.59 3-96 X-ray 1.40 monomer 1 x ATR, 1 x TOP BLAST 0.41
4kl9.1.A
Dihydrofolate reductase
Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in the space group C2
 0.36 40.43 0.59 3-96 X-ray 1.39 monomer 1 x NDP, 1 x P33 BLAST 0.41
5sd2.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1236 (enantiomer)
 0.34 40.43 0.59 3-96 X-ray 2.00 monomer 1 x NAP, 1 x HJI BLAST 0.41
5scm.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-22
 0.34 40.43 0.59 3-96 X-ray 1.65 monomer 1 x GHU, 1 x NAP BLAST 0.41
5scp.1.A
Dihydrofolate reductase
Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-23
 0.35 40.43 0.59 3-96 X-ray 1.80 monomer 1 x NAP, 1 x GWL BLAST 0.41
2cig.1.A
DIHYDROFOLATE REDUCTASE
Dihydrofolate reductase from Mycobacterium tuberculosis inhibited by the acyclic 4R isomer of INH-NADP a derivative of the prodrug isoniazid.
 0.34 39.36 0.59 3-96 X-ray 1.90 monomer 1 x 1DG BLAST 0.41
1cz3.1.A
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA
 0.27 45.45 0.55 23-113 X-ray 2.10 homo-dimer BLAST 0.42
1d1g.1.B
DIHYDROFOLATE REDUCTASE
DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA
 0.28 45.45 0.55 23-113 X-ray 2.10 homo-dimer 2 x NDP, 2 x MTX BLAST 0.42
3qfx.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Trypanosoma brucei dihydrofolate reductase pyrimethamine complex
 0.23 40.00 0.41 4-68 X-ray 2.20 monomer 1 x NDP, 1 x CP6 BLAST 0.42
3rg9.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Trypanosoma brucei dihydrofolate reductase (TbDHFR) in complex with WR99210
 0.23 40.00 0.41 4-68 X-ray 2.00 monomer 1 x NDP, 1 x WRA BLAST 0.42
3irm.2.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH Cycloguanil
 0.21 47.62 0.40 3-65 X-ray 2.10 homo-dimer 2 x 1CY BLAST 0.43
3irn.1.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH NADPH AND Cycloguanil
 0.22 47.62 0.40 3-65 X-ray 2.60 homo-dimer 2 x 1CY, 2 x NDP BLAST 0.43
3irn.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH NADPH AND Cycloguanil
 0.21 47.62 0.40 3-65 X-ray 2.60 homo-dimer 2 x 1CY, 2 x NDP BLAST 0.43
3irn.2.A
Bifunctional dihydrofolate reductase-thymidylate synthase
Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH NADPH AND Cycloguanil
 0.21 47.62 0.40 3-65 X-ray 2.60 homo-dimer 2 x 1CY, 2 x NDP BLAST 0.43
3irn.2.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH NADPH AND Cycloguanil
 0.22 47.62 0.40 3-65 X-ray 2.60 homo-dimer 2 x 1CY, 2 x NDP BLAST 0.43
3inv.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH NADPH, dUMP AND C-448 ANTIFOLATE
 0.21 47.62 0.40 3-65 X-ray 2.37 homo-dimer 2 x C50, 2 x NDP, 2 x UMP BLAST 0.43
3cl9.2.B
Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS)
Structure of bifunctional TcDHFR-TS in complex with MTX
 0.22 46.03 0.40 3-65 X-ray 3.30 homo-dimer 2 x NAP, 2 x MTX, 2 x UMP BLAST 0.42
3clb.2.A
DHFR-TS
Structure of bifunctional TcDHFR-TS in complex with TMQ
 0.22 46.03 0.40 3-65 X-ray 3.00 homo-dimer 2 x NAP, 2 x TMQ BLAST 0.42
3clb.1.A
DHFR-TS
Structure of bifunctional TcDHFR-TS in complex with TMQ
 0.21 46.03 0.40 3-65 X-ray 3.00 homo-dimer 2 x NAP, 2 x TMQ BLAST 0.42
3clb.1.B
DHFR-TS
Structure of bifunctional TcDHFR-TS in complex with TMQ
 0.21 46.03 0.40 3-65 X-ray 3.00 homo-dimer 2 x NAP, 2 x TMQ BLAST 0.42
2h2q.1.B
Bifunctional dihydrofolate reductase-thymidylate synthase
Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate synthase
 0.20 46.03 0.40 3-65 X-ray 2.40 homo-dimer 2 x NAP, 2 x DU BLAST 0.42
6rum.1.A
GFP-LAMA-G97 a GFP enhancer nanobody with cpDHFR insertion
Crystal structure of GFP-LAMA-G97 - a GFP enhancer nanobody with cpDHFR insertion and TMP and NADPH
 0.05 41.67 0.15 2-25 X-ray 1.60 monomer 1 x TOP, 1 x NDP HHblits 0.43
6rul.1.A
GFP-LAMA-F98 a GFP enhancer nanobody with cpDHFR insertion,Dihydrofolate reductase,GFP-LAMA-F98 a GFP enhancer nanobody with cpDHFR insertion,Dihydrofolate reductase,Dihydrofolate reductase,GFP-LAMA-F98 a GFP enhancer nanobody with cpDHFR insertion,Dihydrofolate reductase,GFP-LAMA-F98 a GFP enhancer nanobody with cpDHFR insertion
Crystal structure of GFP-LAMA-F98 - a GFP enhancer nanobody with cpDHFR insertion and TMP and NADPH
 0.05 43.48 0.14 2-24 X-ray 2.20 monomer 1 x TOP, 1 x NDP HHblits 0.44